Salicylanilides: selective inhibitors of interleukin-12p40 production

Bioorganic & Medicinal Chemistry
Michael E BrownJim P Boyce

Abstract

Interleukin (IL)-12p40, a subunit component of both IL-12 and IL-23, is being widely studied for its role in inflammatory disease. As part of an effort to profile cellular signaling pathways across different cell types, we report salicylanilide inhibitors of IL-12p40 production in stimulated dendritic cells. Based on a hypothesis that a desirable therapeutic profile is one that could block IL-12p40 but not IL-6 production, we engaged in directed analoging. This resulted in salicylanilides with similar IL-12p40 related potency but enhanced selectivity relative to IL-6 production.

References

Jan 18, 2003·Science·Chandrashekhar Pasare, Ruslan Medzhitov
Feb 28, 2004·European Journal of Medicinal Chemistry·Christoph LiechtiPeter Traxler
Nov 13, 2004·The New England Journal of Medicine·Peter J MannonUNKNOWN Anti-IL-12 Crohn's Disease Study Group
Oct 19, 2006·Archiv der Pharmazie·Karel WaisserMilan Miko
Nov 28, 2006·Trends in Immunology·Andrea M Cooper, Shabaana A Khader

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Citations

Sep 21, 2013·Bioorganic & Medicinal Chemistry·Karel PaukJosef Jampílek
Oct 1, 2013·Bioorganic & Medicinal Chemistry·Tomas GonecJosef Jampilek
Jan 10, 2012·Chemical & Pharmaceutical Bulletin·Fatma Abd El-Fattah RagabYassin Mohammed Nissan
May 30, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tomas GonecJosef Jampilek
Aug 9, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tomas GonecJosef Jampilek
Oct 13, 2010·European Journal of Medicinal Chemistry·Martin KrátkýJiřina Stolaříková
Jun 17, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Iveta ZadrazilovaJosef Jampilek
Jan 23, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Christian DankHubert Gstach
Jan 10, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Martin KrátkýJiřina Stolaříková
Nov 13, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jan OtevrelJosef Jampilek
Mar 16, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ales ImramovskyJosef Jampilek

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