PMID: 9557985Apr 29, 1998Paper

Salicylate and quinine selectively increase spontaneous firing rates in secondary auditory cortex

Hearing Research
J J Eggermont, M Kenmochi

Abstract

This study presents firing rates for simultaneously recorded spontaneous and stimulus driven multi-unit activity in primary auditory cortex (AI), anterior auditory field (AAF) and secondary auditory cortex (AII) in cats before and after application of salicylate or quinine. From 21 cats, in three cortical areas simultaneously, a total of 1533 multi-unit files were obtained. The data suggest (1) that both salicylate and quinine significantly increase spontaneous firing rates in AII, whereas in AI and AAF both quinine and salicylate reduced the spontaneous rate; (2) the effect of both drugs was to increase spontaneous rates for recording sites with high characteristic frequency (CF) and a tendency to decrease them for low CF sites; (3) the mean stimulus driven firing rates were not affected by either drug except for a decrease produced by quinine in AI; (4) changes in driven firing rate were positively correlated with changes in spontaneous firing rates. This suggests that tinnitus inducing agents selectively increase spontaneous firing rates in the extralemniscal pathway.

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Citations

Mar 23, 2011·Archives of Otolaryngology--head & Neck Surgery·Jay F PiccirilloEdward L Spitznagel
Jun 19, 2008·HNO·G HesseA Laubert
May 26, 2004·Hearing Research·Kamakshi V Gopal, Guenter W Gross
Jul 6, 2000·Progress in Neurobiology·Y Cazals
Aug 30, 2000·Hearing Research·C A BauerD M Caspary
Sep 3, 2002·Hearing Research·Samuel A ReyesAlan H Lockwood
Jan 25, 2003·Auris, Nasus, Larynx·Jos J Eggermont
Jan 25, 2003·Auris, Nasus, Larynx·Kentaro OchiToru Ohashi
Aug 31, 2012·Current Opinion in Otolaryngology & Head and Neck Surgery·Alexander V GalazyukMohamed A Hamid
Nov 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Larry E RobertsJames A Kaltenbach
Nov 17, 2009·Journal of Neurosurgery·Dirk De RidderPaul van de Heyning
Oct 24, 2007·International Journal of Medical Sciences·Dirk De RidderAage Moller
Oct 24, 2007·International Journal of Medical Sciences·Dirk De RidderAage Moller
Oct 27, 2012·Hearing Research·Navzer D EngineerMichael P Kilgard
Feb 19, 2013·Hearing Research·Carol A BauerThomas J Brozoski
Jun 24, 2009·Hearing Research·C P LantingP van Dijk
Mar 17, 2010·Neurophysiologie clinique = Clinical neurophysiology·B LangguthG Hajak
Jan 24, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Grzegorz R Juszczak, Artur H Swiergiel
Apr 20, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Mia T MinenZeina Chemali
Mar 3, 2015·The European Journal of Neuroscience·Jos J Eggermont
Apr 16, 2013·Neuroscience Letters·Young Min ParkJae Yun Jung
Oct 1, 2014·Cell and Tissue Research·Jos J Eggermont, Larry E Roberts
Oct 11, 2005·Drug Discovery Today·Jos J Eggermont

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