Salicylate-induced hearing loss and gap detection deficits in rats

Frontiers in Neurology
Kelly E RadziwonR Salvi

Abstract

To test the "tinnitus gap-filling" hypothesis in an animal psychoacoustic paradigm, rats were tested using a go/no-go operant gap detection task in which silent intervals of various durations were embedded within a continuous noise. Gap detection thresholds were measured before and after treatment with a dose of sodium salicylate (200 mg/kg) that reliably induces tinnitus in rats. Noise-burst detection thresholds were also measured to document the amount of hearing loss and aid in interpreting the gap detection results. As in the previous human psychophysical experiments, salicylate had little or no effect on gap thresholds measured in broadband noise presented at high-stimulus levels (30-60 dB SPL); gap detection thresholds were always 10 ms or less. Salicylate also did not affect gap thresholds presented in narrowband noise at 60 dB SPL. Therefore, rats treated with a dose of salicylate that reliably induces tinnitus have no difficulty detecting silent gaps as long as the noise in which they are embedded is clearly audible.

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Citations

Aug 15, 2015·Psychophysiology·Yunseo KuHee Chan Kim
Oct 1, 2014·Cell and Tissue Research·Jos J Eggermont, Larry E Roberts
Feb 11, 2018·Molecular and Cellular Biochemistry·Jiuhan ZhaoXiuli Shang
Jan 10, 2019·Journal of Neurophysiology·Paulo Vianney-RodriguesRichard Salvi
Nov 4, 2016·Journal of the Association for Research in Otolaryngology : JARO·Aikeen Jones, Bradford J May
Oct 13, 2020·Frontiers in Neuroscience·Ryan J LongeneckerJonathan Kil
Jan 20, 2021·American Journal of Audiology·Richard SalviGuang-Di Chen
Apr 1, 2018·Hearing Research·Ryan J LongeneckerAlexander V Galazyuk
Jun 9, 2021·Brain Structure & Function·Björn Herrmann, Blake E Butler

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Software Mentioned

MATLAB
TDT
Windows XP
- PPI
Gap
TDT RPvds

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