PMID: 7547179Feb 1, 1995Paper

Salicylate poisoning: two-dimensional J-resolved NMR urinalysis

NMR in Biomedicine
S MaschkeM Lhermitte

Abstract

Identification of a case of acute salicylate intoxication using 300 MHz 1H NMR spectroscopy of a urine sample is reported. It has been achieved by using a combination of a one-dimensional experiment with water presaturation and a two-dimensional homonuclear J-resolved experiment. By these means, lysine and the three major metabolites of acetylsalicylic acid have been assigned in the crude urine. The results are compared with those obtained at 600 MHz and with classical biochemical methods. The use of this method for routine diagnosis in biological analysis is discussed.

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Citations

Mar 4, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·S MeshitsukaK Takeshita
May 14, 2003·Forensic Science International : Synergy·M ImbenotteM Lhermitte
Feb 7, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Xiaoyu ZhangFengkui Pei
Jan 7, 2004·Journal of Toxicology. Clinical Toxicology·Michel ImbenotteMichel Lhermitte

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