Salicylic acid as an effective elicitor for improved taxol production in endophytic fungus Pestalotiopsis microspora

PloS One
Kamalraj SubbanJayabaskaran Chelliah

Abstract

Salicylic acid (SA) is an effective elicitor to increase taxol production in Pestalotiopsis microspora. Addition of SA at the concentration of 300 μM yielded taxol 625.47 μg L-1, 45- fold higher than that of the control. Elicitation of the role of SA in the fungal taxol biosynthetic pathway revealed that SA enhanced reactive oxygen species and lipid peroxidation of unsaturated fatty acids of P. microspora mycelia. This oxidative process stimulates isoprene biosynthetic pathway by triggering expression of the geranylgeranyl pyrophosphate synthase gene leading to improved biosynthesis of taxol in P. microspora.

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Citations

Jan 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anket SharmaMarco Landi
Mar 30, 2020·Applied Microbiology and Biotechnology·Zhangqing SongXiaoping Yu
Aug 19, 2021·Journal of the Science of Food and Agriculture·María Belén VázquezJosé Manuel López-Nicolás

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Datasets Mentioned

BETA
HM802304

Methods Mentioned

BETA
MDA
electrophoresis
PCR

Software Mentioned

SPSS
SPSS Base

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