Salicylic acid-independent ENHANCED DISEASE SUSCEPTIBILITY1 signaling in Arabidopsis immunity and cell death is regulated by the monooxygenase FMO1 and the Nudix hydrolase NUDT7

The Plant Cell
Michael BartschJane E Parker

Abstract

Arabidopsis thaliana ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1) controls defense activation and programmed cell death conditioned by intracellular Toll-related immune receptors that recognize specific pathogen effectors. EDS1 is also needed for basal resistance to invasive pathogens by restricting the progression of disease. In both responses, EDS1, assisted by its interacting partner, PHYTOALEXIN-DEFICIENT4 (PAD4), regulates accumulation of the phenolic defense molecule salicylic acid (SA) and other as yet unidentified signal intermediates. An Arabidopsis whole genome microarray experiment was designed to identify genes whose expression depends on EDS1 and PAD4, irrespective of local SA accumulation, and potential candidates of an SA-independent branch of EDS1 defense were found. We define two new immune regulators through analysis of corresponding Arabidopsis loss-of-function insertion mutants. FLAVIN-DEPENDENT MONOOXYGENASE1 (FMO1) positively regulates the EDS1 pathway, and one member (NUDT7) of a family of cytosolic Nudix hydrolases exerts negative control of EDS1 signaling. Analysis of fmo1 and nudt7 mutants alone or in combination with sid2-1, a mutation that severely depletes pathogen-induced SA production, points to SA-ind...Continue Reading

References

Apr 1, 1993·Toxicology Letters·C Richter, J Schlegel
Oct 11, 1996·The Journal of Biological Chemistry·M J BessmanS F O'Handley
Oct 6, 1997·Archives of Biochemistry and Biophysics·A KuboT Kamataki
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·N AartsJ E Parker
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·J K SuhJ D Robertus
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·A FalkJ E Parker
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·D JirageJ Glazebrook
Apr 25, 2002·Proceedings of the National Academy of Sciences of the United States of America·Claudia NaumannDietrich Ober
May 9, 2002·FEBS Letters·Marco W FraaijeDick B Janssen
Jul 26, 2002·Archives of Biochemistry and Biophysics·Man Zhang, Jon D Robertus
Apr 16, 2003·The Plant Journal : for Cell and Molecular Biology·Jane GlazebrookFumiaki Katagiri
Jun 24, 2003·Trends in Plant Science·Séverine LorrainDominique Roby
Jun 25, 2003·Biochemical and Biophysical Research Communications·Hack Sun ChoiSi Wouk Kim
Apr 17, 2004·The Plant Journal : for Cell and Molecular Biology·Julia C RedmanChristopher D Town
Jun 18, 2004·Immunological Reviews·Thorsten NürnbergerLizelle Piater
Jul 3, 2004·Current Opinion in Plant Biology·Youssef BelkhadirJeffery L Dangl
Jul 21, 2004·Briefings in Bioinformatics·Sudhir KumarMasatoshi Nei
Sep 1, 2004·Current Opinion in Plant Biology·Xinnian Dong
Sep 24, 2004·The International Journal of Biochemistry & Cell Biology·Muhammet BektaşEngin Bermek
Sep 28, 2004·The Plant Journal : for Cell and Molecular Biology·Jong Tae SongJean T Greenberg
Sep 28, 2004·The Plant Journal : for Cell and Molecular Biology·Peter CoppingerBrian J Staskawicz
Nov 25, 2004·The Journal of Biological Chemistry·Anne-Laure PerraudAndrew M Scharenberg
Dec 18, 2004·Plant Molecular Biology·Claus-Peter WitteTina Romeis
Dec 22, 2004·The Plant Journal : for Cell and Molecular Biology·Marc De BlockMarc Cornelissen
May 10, 2005·The Journal of Biological Chemistry·Takahisa OgawaShigeru Shigeoka
Jun 1, 2005·Plant Physiology·Peter BrodersenJohn Mundy
Jun 9, 2005·Current Opinion in Plant Biology·Marcel WiermerJane E Parker

❮ Previous
Next ❯

Citations

Jan 20, 2012·Molecular Genetics and Genomics : MGG·Iris FechterReinhard Töpfer
Jan 17, 2013·Applied Biochemistry and Biotechnology·Xiu-Chun ZhangMing Peng
May 11, 2013·Journal of Biosciences·Mehanathan Muthamilarasan, Manoj Prasad
Jul 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Zhaohai ZhuYuelin Zhang
Nov 23, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sungbeom LeeDorothea Tholl
Oct 19, 2011·Proceedings of the National Academy of Sciences of the United States of America·Yin ChenJ Colin Murrell
Apr 23, 2011·Journal of Experimental Botany·Jeong Im KimMeena L Narasimhan
Sep 20, 2008·Plant & Cell Physiology·Francisco José MuñozJavier Pozueta-Romero
Apr 3, 2010·Plant & Cell Physiology·Jacqueline Monaghan, Xin Li
Feb 10, 2012·Molecular Plant-microbe Interactions : MPMI·Manon MoreauMathilde Fagard
Feb 23, 2007·Molecular Plant-microbe Interactions : MPMI·Colleen KnothThomas Eulgem
Dec 5, 2006·Plant Physiology·Dawn LittlePhilippe Reymond
Sep 26, 2008·Plant Physiology·Takahisa OgawaShigeru Shigeoka
Jun 26, 2012·Plant Physiology·Alberto P MachoCyril Zipfel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis