Salicylic acid-independent role of NPR1 is required for protection from proteotoxic stress in the plant endoplasmic reticulum

Proceedings of the National Academy of Sciences of the United States of America
YaShiuan LaiFederica Brandizzi

Abstract

The unfolded protein response (UPR) is an ancient signaling pathway designed to protect cells from the accumulation of unfolded and misfolded proteins in the endoplasmic reticulum (ER). Because misregulation of the UPR is potentially lethal, a stringent surveillance signaling system must be in place to modulate the UPR. The major signaling arms of the plant UPR have been discovered and rely on the transcriptional activity of the transcription factors bZIP60 and bZIP28 and on the kinase and ribonuclease activity of IRE1, which splices mRNA to activate bZIP60. Both bZIP28 and bZIP60 modulate UPR gene expression to overcome ER stress. In this study, we demonstrate at a genetic level that the transcriptional role of bZIP28 and bZIP60 in ER-stress responses is antagonized by nonexpressor of PR1 genes 1 (NPR1), a critical redox-regulated master regulator of salicylic acid (SA)-dependent responses to pathogens, independently of its role in SA defense. We also establish that the function of NPR1 in the UPR is concomitant with ER stress-induced reduction of the cytosol and translocation of NPR1 to the nucleus where it interacts with bZIP28 and bZIP60. Our results support a cellular role for NPR1 as well as a model for plant UPR regulati...Continue Reading

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Citations

Sep 16, 2018·The Plant Journal : for Cell and Molecular Biology·Evan Angelos, Federica Brandizzi
Nov 5, 2019·Journal of Experimental Botany·Taiaba AfrinKarolina Pajerowska-Mukhtar
Jul 8, 2020·International Journal of Molecular Sciences·Igor PokotyloEric Ruelland
Nov 27, 2019·International Journal of Molecular Sciences·Péter PoórAttila Ördög
Sep 27, 2018·Nature Communications·Ya-Shiuan LaiFederica Brandizzi
Oct 25, 2020·The Plant Journal : for Cell and Molecular Biology·Dae Kwan Ko, Federica Brandizzi
Nov 3, 2020·Molecular Plant·Jing-Liang SunJian-Xiang Liu
Nov 5, 2020·International Journal of Molecular Sciences·Alexander I KostyukDmitry S Bilan
Nov 18, 2020·Proceedings of the National Academy of Sciences of the United States of America·Mingzhe ShenDae-Jin Yun
Dec 31, 2020·International Journal of Molecular Sciences·Jianguo ZhaoBiao Jin
Nov 23, 2019·Trends in Biochemical Sciences·Noelia Pastor-CantizanoFederica Brandizzi
Feb 26, 2021·The Plant Cell·Carla BrilladaMarco Trujillo
Jul 28, 2021·Journal of Integrative Plant Biology·Xiumei XuLixin Zhang
Dec 18, 2021·The Plant Journal : for Cell and Molecular Biology·Jian LiNan Yao

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