Salidroside, A Natural Antioxidant, Improves β-Cell Survival and Function via Activating AMPK Pathway

Frontiers in Pharmacology
Linjie JuLuan Shu

Abstract

Aim: The enhanced oxidative stress contributes to progression of type 2 diabetes mellitus (T2DM) and induces β-cell failure. Salidroside is a natural antioxidant extracted from medicinal food plant Rhodiola rosea. This study was aimed to evaluate protective effects of salidroside on β-cells against diabetes associated oxidative stress. Methods and Results: In diabetic db/db and high-fat diet-induced mice, we found salidroside ameliorated hyperglycemia and relieved oxidative stress. More importantly, salidroside increased β-cell mass and β-cell replication of diabetic mice. Mechanism study in Min6 cells revealed that, under diabetic stimuli, salidroside suppressed reactive oxygen species production and restore mitochondrial membrane potential (ΔΨm) via reducing NOX2 expression and inhibiting JNK-caspase 3 apoptotic cascade subsequently to protect β-cell survival. Simultaneously, diabetes associated oxidative stress also activated FOXO1 and triggered nuclear exclusion of PDX1 which resulted in β-cell dysfunction. This deleterious result was reversed by salidroside by activating AMPK-AKT to inhibit FOXO1 and recover PDX1 nuclear localization. The efficacy of salidroside in improving β-cell survival and function was further confirm...Continue Reading

References

Sep 15, 1999·Proceedings of the National Academy of Sciences of the United States of America·Y TanakaR P Robertson
Oct 17, 2001·The Journal of Clinical Investigation·G ZhouD E Moller
Mar 19, 2003·The Journal of Biological Chemistry·Vasilij KoshkinMichael B Wheeler
Jun 5, 2003·American Journal of Physiology. Endocrinology and Metabolism·Jennifer AltomonteHengjiang Dong
Sep 19, 2006·The International Journal of Biochemistry & Cell Biology·Marian ValkoJoshua Telser
Mar 21, 2007·Chemistry & Biodiversity·Peizhong YuLiqing Chen
Oct 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Mira M SachdevaDoris A Stoffers
Dec 3, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fenglin LiXiangle Meng
Jul 7, 2012·Molecular and Cellular Endocrinology·Accalia FuRobert A Screaton
Jul 7, 2012·Trends in Endocrinology and Metabolism : TEM·Sachin SupalePierre Maechler
Jan 15, 2014·Journal of Cellular Biochemistry·Shiying ShaoYan Yang
Jan 15, 2014·Molecular Cancer Therapeutics·Xiaona LiuBiplab Dasgupta
Aug 17, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Magali BalteauChristophe Beauloye
Oct 15, 2014·Current Medicinal Chemistry·Jianbo Xiao
May 1, 2015·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Shih-Yu LeeTsu-Chung Chang
Jul 24, 2015·Molecular Nutrition & Food Research·Ching-Hsia HungKun-Ling Tsai
Sep 4, 2015·Apoptosis : an International Journal on Programmed Cell Death·Feng HaoXuejun Li
Dec 3, 2015·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Anthony BookerMichael Heinrich
May 27, 2016·Antioxidants & Redox Signaling·Philipp A Gerber, Guy A Rutter
Oct 26, 2016·Recent Patents on Endocrine, Metabolic & Immune Drug Discovery·Vaibhav Sidarala, Anjaneyulu Kowluru

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Citations

Jul 17, 2020·Journal of Cardiovascular Translational Research·Fangying YanXiufang Gao
Oct 16, 2019·Oxidative Medicine and Cellular Longevity·Gen-Xiang MaoJing Yan
Apr 11, 2019·The American Journal of Chinese Medicine·Hsiu-Chung OuChih-Yang Huang
Mar 31, 2021·Chinese Journal of Natural Medicines·Chun-Xia LiangZhi-Dong Liu
Aug 3, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Akurange Sujeevi Dammadinna WickramasingheAnoja Priyadarshani Attanayake
Aug 8, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jie SunYan Yang
Jul 23, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Manli HuZhili Qi

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Methods Mentioned

BETA
blood drawn
ELISA
flow cytometry
MDA
transfection
nuclear translocation

Software Mentioned

NIS
Elements

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