Salidroside ameliorates insulin resistance through activation of a mitochondria-associated AMPK/PI3K/Akt/GSK3β pathway

British Journal of Pharmacology
Tao ZhengSi Jin

Abstract

Recent reports have suggested that salidroside could protect cardiomyocytes from oxidative injury and stimulate glucose uptake in skeletal muscle cells by activating AMP-activated protein kinase (AMPK). The aim of this study was to evaluate the therapeutic effects of salidroside on diabetic mice and to explore the underlying mechanisms. The therapeutic effects of salidroside on type 2 diabetes were investigated. Increasing doses of salidroside (25, 50 and 100 mg·kg(-1) ·day(-1)) were administered p.o. to db/db mice for 8 weeks. Biochemical analysis and histopathological examinations were conducted to evaluate the therapeutic effects of salidroside. Primary cultured mouse hepatocytes were used to further explore the underlying mechanisms in vitro. Salidroside dramatically reduced blood glucose and serum insulin levels and alleviated insulin resistance. Hypolipidaemic effects and amelioration of liver steatosis were observed after salidroside administration. In vitro, salidroside dose-dependently induced an increase in the phosphorylations of AMPK and PI3K/Akt, as well as glycogen synthase kinase 3β (GSK3β) in hepatocytes. Furthermore, salidroside-stimulated AMPK activation was found to suppress the expression of PEPCK and glucos...Continue Reading

References

Jul 27, 2001·Diabetes·G MarchesiniN Melchionda
Apr 20, 2005·Lancet·Robert H EckelPaul Z Zimmet
Feb 8, 2006·Annual Review of Physiology·Sudha B Biddinger, C Ronald Kahn
Feb 24, 2006·Endocrine Reviews·Julie NigroPeter J Little
Jul 11, 2006·The Journal of Clinical Investigation·Clay F Semenkovich
Aug 15, 2006·The Journal of Clinical Investigation·Michihiro MatsumotoDomenico Accili
Feb 20, 2007·Circulation Research·Mhairi C Towler, D Grahame Hardie
Apr 18, 2007·Proceedings of the National Academy of Sciences of the United States of America·Biplab Dasgupta, Jeffrey Milbrandt
Apr 10, 2010·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·A PanossianJ Sarris
Jul 8, 2010·The Journal of Gene Medicine·Carol KilkennyUNKNOWN NC3Rs Reporting Guidelines Working Group
Jul 17, 2010·The Journal of Physiology·UNKNOWN NC3Rs Reporting Guidelines Working Group
Jul 24, 2010·British Journal of Pharmacology·J C McGrathC L Wainwright
Jul 24, 2010·British Journal of Pharmacology·Carol KilkennyUNKNOWN NC3Rs Reporting Guidelines Working Group
Jun 10, 2011·Nature·Mirko TrajkovskiMarkus Stoffel
Jun 18, 2011·Science·Jonathan S OakhillBruce E Kemp
Sep 24, 2011·Diabetes·Dae Hyun KimH Henry Dong
Dec 3, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fenglin LiXiangle Meng

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Citations

Mar 8, 2016·European Journal of Pharmacology·Xin-ru ZhangXiao-hong Yang
Mar 2, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Qingpu LiuGuoping Peng
Apr 18, 2019·Journal of Cellular and Molecular Medicine·Xinzhong HuangCheng Sun
Sep 5, 2019·Mini Reviews in Medicinal Chemistry·Xiang-Li BaiSi Jin
Feb 6, 2020·Experimental and Therapeutic Medicine·In-Hye KimTaek-Jeong Nam
Mar 4, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Hongshan LiYaoren Hu
Jul 26, 2017·Journal of Molecular Neuroscience : MN·Gui-Lian NiZhong-Min Wu
Mar 30, 2018·Frontiers in Pharmacology·Peng ZhangXiaoping Chen
Dec 14, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Sang Mi ParkIl Je Cho
Apr 4, 2019·Frontiers in Pharmacology·Futian XuHeqing Huang

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