Salidroside Attenuates Doxorubicin-Induced Cardiac Dysfunction Partially Through Activation of QKI/FoxO1 Pathway.

Journal of Cardiovascular Translational Research
Fangying YanXiu-Fang Gao

Abstract

Doxorubicin (DOX) is an effective chemotherapy. However, its usage has been associated with adverse effects. Salidroside (SAL) is an antioxidative drug, which confers protective effects against several diseases. Salidroside can attenuate cardiac dysfunction induced by DOX. Quaking (QKI) is identified as a protective factor that can inhibit cardiotoxicity medicated by DOX through the regulation of cardiac circular RNA expression. The present study investigated the role of QKI on the protective effect of SAL in the DOX-induced cardiotoxicity model. Results indicated that SAL attenuated DOX-induced adverse effects, including cardiac dysfunction, weight loss, and reactive oxygen species (ROS) production, and decreased the expression of BAX, caspase 3, and FoxO1. Also, it increased the Mn-SOD2 and QKI expression in vivo and in vitro. Furthermore, QKI knockdown suppressed anti-cardiotoxicity mediated by SAL. In conclusion, the results of the current study show that salidroside attenuates doxorubicin-induced cardiac dysfunction through activation of QKI/FoxO1 pathway.

References

Mar 21, 1991·The New England Journal of Medicine·S E LipshultzS P Sanders
Jul 26, 2005·Nature Structural & Molecular Biology·André Galarneau, Stéphane Richard
May 23, 2007·Expert Opinion on Pharmacotherapy·Elly BarrySteven E Lipshultz
May 22, 2009·BMC Molecular Biology·André Galarneau, Stéphane Richard
Mar 29, 2011·Biochimica Et Biophysica Acta·Xinbo ZhangArun K Rishi
Dec 20, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Wangang GuoZifan Lu
Feb 20, 2013·Journal of Asian Natural Products Research·Mao-Chun XuHao Wang
Jun 18, 2016·Cancer Biomarkers : Section a of Disease Markers·Cai LvZhi-Ming Bai
Jul 2, 2018·Journal of Pharmacological Sciences·Yan SunLei Shi
Aug 26, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Chuanhong LuoDingkun Zhang

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