Salidroside Attenuates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease via AMPK-Dependent TXNIP/NLRP3 Pathway

Oxidative Medicine and Cellular Longevity
Tao ZhengSi Jin

Abstract

Our previous studies suggested that salidroside could alleviate hepatic steatosis in type 2 diabetic C57BLKS/Leprdb (db/db) mice. The aim of the present study was to evaluate the therapeutic effect of salidroside on high-fat diet- (HFD-) induced nonalcoholic fatty liver disease (NAFLD) by investigating underlying mechanisms. Mice were fed with HFD or regular diet, randomly divided into two groups, and treated with salidroside or vehicle for 8 weeks. Then, biochemical analyses and histopathological examinations were conducted in vivo and in vitro. Salidroside administration attenuated HFD-induced obesity, blood glucose variability, and hepatic lipid deposition, markedly increasing insulin sensitivity in HFD mice. In addition, salidroside suppressed oxidative stress, thioredoxin-interacting protein (TXNIP) expression, and NLRP3 inflammasome activation in the liver. In cultured hepatocytes, salidroside dose dependently regulated lipid accumulation, reactive oxygen species (ROS) generation, and NLRP3 inflammasome activation as well as improved AMP-activated protein kinase (AMPK) activity and insulin sensitivity. The inhibition of AMPK activation by inhibitor or short interfering RNA (siRNA) resulted in the suppression of the benefi...Continue Reading

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Citations

Nov 1, 2020·The Kaohsiung Journal of Medical Sciences·Rui-Kai LiangRui-Jing Liang
Jan 28, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hongshan LiYiyang Hu
Sep 11, 2020·Archives of Physiology and Biochemistry·Xinyong SuWeihua Bian
Jul 17, 2020·Journal of Cardiovascular Translational Research·Fangying YanXiufang Gao
Aug 18, 2021·International Journal of Immunopathology and Pharmacology·Yongxiang YuXiaohui Dong
Aug 27, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jing QianChun Liu
Jul 23, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Manli HuZhili Qi

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Methods Mentioned

BETA
MDA
ELISA
PCR
transfection

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