Salience-Default Mode Functional Network Connectivity Linked to Positive and Negative Symptoms of Schizophrenia.

Schizophrenia Bulletin
Stephanie M HareJessica A Turner

Abstract

Schizophrenia is a complex, debilitating mental disorder characterized by wide-ranging symptoms including delusions, hallucinations (so-called positive symptoms), and impaired motor and speech/language production (so-called negative symptoms). Salience-monitoring theorists propose that abnormal functional communication between the salience network (SN) and default mode network (DMN) begets positive and negative symptoms of schizophrenia, yet prior studies have predominately reported links between disrupted SN/DMN functional communication and positive symptoms. It remains unclear whether disrupted SN/DMN functional communication explains (1) solely positive symptoms or (2) both positive and negative symptoms of schizophrenia. To address this question, we incorporate time-lag-shifted functional network connectivity (FNC) analyses that explored coherence of the resting-state functional magnetic resonance imaging signal of 3 networks (anterior DMN, posterior DMN, and SN) with fixed time lags introduced between network time series (1 TR = 2 s; 2 TR = 4 s). Multivariate linear regression analysis revealed that severity of disordered thought and attentional deficits were negatively associated with 2 TR-shifted FNC between anterior DMN...Continue Reading

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Citations

May 17, 2019·Neurocase·Byron BernalMichael Duchowny
Jul 18, 2020·Psychological Medicine·Yong-Ming WangRaymond C K Chan
Aug 4, 2020·Schizophrenia Bulletin·Matthias KirschnerBratislav Mišić
Oct 2, 2019·Frontiers in Neurology·Stéphane PotvinOvidiu Lungu
Jun 14, 2020·Neuroscience and Biobehavioral Reviews·Indrit BègueMatthias Kirschner
Apr 4, 2021·Journal of Clinical Medicine·Byung-Hoon KimJae-Jin Kim
Apr 6, 2021·Frontiers in Neural Circuits·Mohammad S E SendiVince D Calhoun
Jul 31, 2021·Schizophrenia Research·Aniol Santo-AnglesJens Schwarzbach
Sep 12, 2021·Seminars in Cell & Developmental Biology·Lena Palaniyappan

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