Salinomycin in cancer: A new mission for an old agent

Molecular Medicine Reports
Cord NaujokatGerhard Opelz


Salinomycin is a monocarboxylic polyether ionophore isolated from Streptomyces albus that has been used for more than 30 years as an agricultural antibiotic to prevent coccidiosis in poultry and to improve nutrient absorption and feed efficiency in ruminants and swine. As a inonophore with strict selectivety for alkali ions and a strong preference for potassium, salinomycin interferes with transmembrane potassium potential and promotes the efflux of K+ ions from mitochondria and cytoplasm. Salinomycin has recently been shown to kill human cancer stem cells and to inhibit breast cancer growth and metastasis in mice. Salinomycin is also able to induce massive apoptosis in human cancer cells of different origins that display multiple mechanisms of drug and apoptosis resistance. Salinomycin activates an unconventional pathway of apoptosis in human cancer cells that may contribute to the breakdown of apoptosis resistance. The ability of salinomycin to effectively kill both cancer stem cells and apoptosis-resistant cancer cells may define the compound as a novel and effective anticancer agent.


Jul 11, 2013·PloS One·Olajumoke Omolara OjoSrikanta Kumar Rath
Mar 8, 2014·European Journal of Medicinal Chemistry·Michał AntoszczakAdam Huczyński
Nov 28, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Michał AntoszczakAdam Huczyński
Feb 22, 2012·Expert Opinion on Drug Delivery·Srinath PalakurthiKiran Kumar Vangara
Sep 27, 2015·Biochemical and Biophysical Research Communications·Hyunsook AnJae Hong Seo
Mar 13, 2014·International Journal of Cancer. Journal International Du Cancer·Anup Kumar SinghDipak Datta
Oct 20, 2012·Bioorganic & Medicinal Chemistry Letters·Adam HuczyńskiBogumil Brzezinski
Feb 17, 2015·Cancer Cell International·Elsa N Garza-TreviñoHerminia G Martínez-Rodríguez
May 9, 2012·Biochimica Et Biophysica Acta·Adam HuczyńskiBogumil Brzezinski
Oct 23, 2015·Cell Death & Disease·A ManagòI Szabò
Sep 29, 2018·Cancers·Vivek KaushikAnand K V Iyer
Dec 4, 2014·Obstetrics & Gynecology Science·Hyun Gyo LeeChi Heum Cho
Feb 13, 2018·Journal of Experimental & Clinical Cancer Research : CR·Jiang JiangZeyao Tang
Feb 22, 2020·Chemistry : a European Journal·Antoine VersiniRaphaël Rodriguez
Feb 10, 2018·Oncotarget·Johannes KloseAlexis Ulrich
Jun 14, 2019·Archives of Toxicology·Johannes DelpMarcel Leist
Dec 30, 2014·The Journal of Biological Chemistry·Collynn F WoellerRichard P Phipps
Jun 4, 2019·Parasitology Research·Sandra NoackPaul M Selzer
Jan 6, 2019·European Journal of Medicinal Chemistry·Michał Antoszczak
Nov 12, 2020·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Huan ShenJunbo Gong
Oct 6, 2018·Toxicology and Applied Pharmacology·Kwang-Youn KimYoung Woo Kim

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.


Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis