Salinomycin inhibits proliferation and induces apoptosis of human nasopharyngeal carcinoma cell in vitro and suppresses tumor growth in vivo

Biochemical and Biophysical Research Communications
Danxin WuSenming Wang

Abstract

Salinomycin (Sal) is a polyether ionophore antibiotic that has recently been shown to induce cell death in various human cancer cells. However, whether salinomycin plays a functional role in nasopharyngeal carcinoma (NPC) has not been determined to date. The present study investigated the chemotherapeutic efficacy of salinomycin and its molecular mechanisms of action in NPC cells. Salinomycin efficiently inhibited proliferation and invasion of 3 NPC cell lines (CNE-1, CNE-2, and CNE-2/DDP) and activated a extensive apoptotic process that is accompanied by activation of caspase-3 and caspase-9, and decreased mitochondrial membrane potential. Meanwhile, the protein expression level of the Wnt coreceptor lipoprotein receptor related protein 6 (LRP6) and β-catenin was down-regulated, which showed that the Wnt/β-catenin signaling was involved in salinomycin-induced apoptosis of NPC cells. In a nude mouse NPC xenograft model, the anti-tumor effect of salinomycin was associated with the downregulation of β-catenin expression. The present study demonstrated that salinomycin can effectively inhibit proliferation and invasion, and induce apoptosis of NPC cells in vitro and inhibit tumor growth in vivo, probably via the inhibition of Wnt/...Continue Reading

References

Apr 1, 1976·Antimicrobial Agents and Chemotherapy·M MitaniN Otake
Oct 27, 1975·Biochemical and Biophysical Research Communications·M MitaniY Miyazaki
Aug 15, 1998·Biochemical and Biophysical Research Communications·S D BrownJ F Hess
Nov 1, 2000·Cell·M Bienz, H Clevers
Dec 21, 2000·International Journal of Radiation Oncology, Biology, Physics·S H ChengA T Huang
Jun 28, 2002·Cancer Cell·Ashani T WeeraratnaJeffrey M Trent
May 18, 2004·Cancer Cell·Kwok Wai LoDolly P Huang
Jul 28, 2004·Trends in Microbiology·Pierre BussonMarilys Corbex
Apr 20, 2005·Cancer Letters·Julien MazieresDavid M Jablons
Jan 24, 2006·Biochemical and Biophysical Research Communications·Yu-Ching LinDavid M Jablons
Dec 26, 2006·Cellular Signalling·Akira KikuchiShosei Kishida
May 1, 2008·Head & Neck·Josephine ChouDavid M Jablons
Oct 20, 2009·Biochemical and Biophysical Research Communications·Dominik FuchsCord Naujokat
Mar 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Chia-Chen LiuGuojun Bu
Mar 31, 2010·Biochemical and Biophysical Research Communications·Dominik FuchsCord Naujokat
Jun 3, 2011·Cell Death & Disease·W Boehmerle, M Endres
Jul 27, 2011·Proceedings of the National Academy of Sciences of the United States of America·Desheng LuDennis A Carson
Aug 13, 2011·Cancer Letters·Qing-Lian TangJin Wang
Oct 15, 2011·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Qiao Ming ZhiYing Yan Yu
Oct 28, 2011·Cancer Letters·Guan-Nan ZhangYu-Pei Zhao
Jan 17, 2012·Biochemical and Biophysical Research Communications·Ju-Hwa KimSungpil Yoon
Feb 9, 2012·Seminars in Cancer Biology·Wei-Hua Jia, Hai-De Qin
Feb 12, 2013·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Lei HeChuan-Yong Guo

❮ Previous
Next ❯

Citations

Nov 28, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Michał AntoszczakAdam Huczyński
Mar 5, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Andressa Megumi NiwaMário Sérgio Mantovani
Aug 31, 2014·Pharmacology & Therapeutics·Phuong N LeAntonio Jimeno
Oct 20, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Fuat Kaplan, Fulya Teksen
Jul 20, 2016·Cancers·Kamal AhmedVladimir L Katanaev
Mar 30, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jayant DewanganSrikanta Kumar Rath
Sep 29, 2018·Cancers·Vivek KaushikAnand K V Iyer
Oct 20, 2017·Journal of Applied Toxicology : JAT·Xin ChenShile Huang
Apr 17, 2019·Pharmaceutical Research·Carolina SousaMafalda Videira
Jan 11, 2020·Frontiers in Cell and Developmental Biology·Tatiana V DenisenkoBoris Zhivotovsky
Jan 11, 2019·International Journal of Molecular Sciences·Edith EmmingsMartina Bazzaro
Jan 6, 2019·European Journal of Medicinal Chemistry·Michał Antoszczak
Aug 31, 2021·Signal Transduction and Targeted Therapy·Fanyuan YuLing Ye

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Tumorigenesis

Breast tumorigenesis involves the production or formation of tumor(s) in breast tissue. Discover the latest research on breast tumorigenesis here.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis