Salinomycin-Loaded Iron Oxide Nanoparticles for Glioblastoma Therapy

Nanomaterials
Mohammad NorouziDonald W Miller

Abstract

Salinomycin is an antibiotic introduced recently as a new and effective anticancer drug. In this study, magnetic iron oxide nanoparticles (IONPs) were utilized as a drug carrier for salinomycin for potential use in glioblastoma (GBM) chemotherapy. The biocompatible polyethylenimine (PEI)-polyethylene glycol (PEG)-IONPs (PEI-PEG-IONPs) exhibited an efficient uptake in both mouse brain-derived microvessel endothelial (bEnd.3) and human U251 GBM cell lines. The salinomycin (Sali)-loaded PEI-PEG-IONPs (Sali-PEI-PEG-IONPs) released salinomycin over 4 days, with an initial release of 44% ± 3% that increased to 66% ± 5% in acidic pH. The Sali-IONPs inhibited U251 cell proliferation and decreased their viability (by approximately 70% within 48 h), and the nanoparticles were found to be effective in reactive oxygen species-mediated GBM cell death. Gene studies revealed significant activation of caspases in U251 cells upon treatment with Sali-IONPs. Furthermore, the upregulation of tumor suppressors (i.e., p53, Rbl2, Gas5) was observed, while TopII, Ku70, CyclinD1, and Wnt1 were concomitantly downregulated. When examined in an in vitro blood-brain barrier (BBB)-GBM co-culture model, Sali-IONPs had limited penetration (1.0% ± 0.08%) throu...Continue Reading

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Citations

Dec 11, 2020·Acta Biomaterialia·Mohammad Norouzi, Pierre Hardy
Feb 5, 2021·International Journal of Pharmaceutics·Mohammad NorouziDonald W Miller
Feb 21, 2021·Drug Discovery Today·Shreya PawarArun K Iyer
Aug 29, 2021·Pharmaceutics·Lucia Ruxandra TefasIoan Tomuță

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Methods Mentioned

BETA
dynamic light scattering
ELISA
protein assay
transmission electron microscopy
flow cytometry
PCR
X-ray

Software Mentioned

Image J

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