Salinomycin may inhibit the cancer stem-like populations with increased chemoradioresistance that nasopharyngeal cancer tumorspheres contain

Oncology Letters
Gong ZhangLei Li

Abstract

Tumor recurrence and metastasis of nasopharyngeal cancer (NPC) often result in the failure of treatment due to chemoradioresistance. Cancer stem cells (CSCs) have been observed to drive tumor initiation and tumor chemoradioresistance. Therefore, the poor prognosis of advanced NPC is likely to result from the failure to kill CSCs. Sphere formation may be used as an experimental method to enrich potential CSC subpopulations. At present, there are few reports on NPC tumorspheres. The present study focused on examining the cancer stem-like properties of NPC tumorspheres from NPC cell lines. Western blot analysis revealed that NPC tumorspheres had a higher expression of stem cell markers Nanog homeobox and SRY-box 2, compared with parental cells. It was additionally verified that NPC tumorspheres contained a high aldehyde dehydrogenase (ALDH) enzymatic activity compared with parental cells. ALDH+ cells were amplified by 9- to 10-fold in tumorspheres, compared with parental cells (1.8 vs. 16.9%). The tumorsphere cells exhibited an increased half maximal inhibitory concentration value of >10-fold with cisplatin compared with the control parental cells. Compared with the parental cells, the percentage of side population cells in the tu...Continue Reading

References

May 21, 2003·Genes & Development·Gabriela DontuMax S Wicha
Dec 4, 2003·Brain Research·Alessandra BezEugenio Agostino Parati
Sep 28, 2006·Annual Review of Medicine·Piero DalerbaMichael F Clarke
Nov 3, 2007·Developmental Biology·Xudong ShiWade Bushman
Jan 26, 2010·Journal of Biotechnology·Franziska HirschhaeuserLeoni A Kunz-Schughart
Jun 30, 2011·Cancer Research·Julie MathieuHannele Ruohola-Baker
Feb 9, 2012·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Burkhard GreveMartin Götte
Sep 4, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Anne W M LeeT H Lam
Aug 13, 2013·Current Medicinal Chemistry·Shuang ZhouErxi Wu
Sep 10, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anne W M LeeAnthony T C Chan
Nov 17, 2015·Hematology/oncology Clinics of North America·Henry SzeAnne W M Lee
Apr 27, 2016·Expert Opinion on Drug Metabolism & Toxicology·Kyle McIntoshAmit K Tiwari
Apr 29, 2016·Chinese Clinical Oncology·Cheng XuJun Ma
Apr 29, 2016·Chinese Clinical Oncology·Wan-Ling TanMei-Kim Ang
May 4, 2016·EMBO Molecular Medicine·Francesca De BaccoCarla Boccaccio
May 27, 2016·Oncoscience·Maximilian BoeschDominik Wolf
Sep 7, 2016·Stem Cells International·Annapurna PranatharthiSweta Srivastava

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯