PMID: 9431589Feb 7, 1998Paper

Saliva: an additional diagnostic tool in Sjögren's syndrome

Seminars in Arthritis and Rheumatism
M TishlerM Yaron

Abstract

To assess the available data and the place of salivary analysis in the diagnosis of Sjögren's syndrome (SS). A Medline search of English language articles published between 1985 and 1996 and a manual search of the reference lists of relevant articles formed the data sources. These were combined with our clinical and experimental experience in this field. Each method of salivary analysis was assessed according to study design, type of saliva used for the study, sensitivity/ specificity for the diagnosis of SS, and correlation to the histopathological findings. Increased levels of salivary Na+, immunoglobulins (particularly IgA), anti-Ro and La antibodies, lactoferrin, lysozyme, beta 2 microglobulin, prostaglandin E2, thromboxane B2, interleukin-6, and hyaluronic acid have been detected in various studies. Results varied according to the different methods used for saliva collection. Although many changes have been detected in various constituents of saliva in SS patients, no test has proved sensitive or specific enough for diagnosing SS.

References

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Citations

Feb 9, 2012·Oral Diseases·T FukushimaI Mataga
Jan 20, 2006·Acta Odontologica Scandinavica·L Miia J HeleniusChristian Lindqvist
Feb 22, 2012·Oral Oncology·Jingyi Liu, Yixiang Duan
May 29, 1999·Archives of Oral Biology·M TishlerM Yaron
Jul 1, 2010·Indian Journal of Medical Sciences·T Deepa, N Thirrunavukkarasu
Jul 11, 2002·Oral Diseases·Roland JonssonPeter Szodoray
Dec 29, 2000·Scandinavian Journal of Rheumatology·R JonssonT P Gordon
Jul 5, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·Eliaz Kaufman, Ira B Lamster
Feb 21, 2018·Biomarkers in Medicine·Chiara BaldiniStefano Bombardieri
Feb 20, 2003·The American Journal of Gastroenterology·Terumi KamisawaNoriko Kamata
May 11, 2002·Biological Research for Nursing·Pamela V O'NealCindy Munro
Nov 10, 2017·Clinical Rheumatology·Tania FidelixVirgínia Trevisani
May 15, 2018·Frontiers in Physiology·Eftychia PappaKonstantinos Vougas
Jun 25, 2021·Frontiers in Medicine·Claudio VitaliNicoletta Del Papa

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