Saliva in the "Omics" era: A promising tool in paediatrics

Oral Diseases
Eftychia PappaHeleni Vastardis

Abstract

In vulnerable populations, such as infants and children, saliva makes the perfect diagnostic medium because of its noninvasive collection, easy handling and storage of samples. Its unique biomarker profiles help tremendously in the diagnosis of many diseases and conditions. In fact, saliva genomics, proteomics, transcriptomics, metabolomics and microbiome-based discoveries have led to complementary and powerful diagnostic information. In children and neonates, saliva is the preferred medium not only for diagnosis of caries and aggressive periodontitis but also for a number of systemic conditions, metabolic diseases, cognitive functions, stress assessment and evaluation of immunological and inflammatory responses to vaccination. In this review, we provide an overview of current and future applications of saliva diagnostics to various diseases and conditions and highlight studies in paediatrics across the "omic" spectrum. Emerging frontiers in salivary diagnostics research that may significantly advance the field are also highlighted.

References

Apr 1, 1967·American Journal of Diseases of Children·I D MandelE V Zegarelli
Feb 24, 2001·The Journal of Prosthetic Dentistry·S P Humphrey, R T Williamson
Apr 9, 2002·Oral Diseases·A V Nieuw Amerongen, E C I Veerman
Nov 12, 2002·The Journal of Prosthetic Dentistry·Ana M Diaz-Arnold, Cindy A Marek
Sep 14, 2007·Stress : the International Journal on the Biology of Stress·David S Jessop, Julie M Turner-Cobb
Dec 20, 2008·Psychoneuroendocrinology·Dirk H HellhammerBrigitte M Kudielka
Jan 3, 2009·Journal of Proteome Research·Paturi V RaoSrinivasa R Nagalla
Mar 3, 2009·Genome Research·Ivan NasidzeMark Stoneking
Jun 30, 2010·Molecular & Cellular Proteomics : MCP·Tiziana CabrasIrene Messana
Dec 3, 2010·Oral Diseases·N Spielmann, D T Wong
Jun 3, 2011·The New England Journal of Medicine·Suresh B BoppanaUNKNOWN National Institute on Deafness and Other Communication Disorders CHIMES Study
Aug 6, 2011·Chest·Rosa M Estrada-Y-Martin, Philip R Orlander
Sep 16, 2011·Advances in Dental Research·B J BaumJ E Melvin
Mar 13, 2012·Journal of Pediatric Nursing·Margaret F Keil
May 24, 2012·Nursing Research and Practice·Sarah WilliamsonR K Elswick
Jul 14, 2012·Operative Dentistry·D T W Wong
Jul 21, 2012·Clinical Endocrinology·Warrick J InderAnthony Russell
Aug 7, 2012·Journal of Dental Research·L M ShaddoxB J Paster
Sep 7, 2012·PLoS Medicine·Kenneth HillUNKNOWN Technical Advisory Group of United Nations Inter-agency Group for Child Mortality Estimation
Jan 11, 2014·Omics : a Journal of Integrative Biology·Betzaida Cuevas-Córdoba, Juan Santiago-García
Jan 11, 2014·Journal of Perinatology : Official Journal of the California Perinatal Association·J Romano-KeelerJ L Maron
Feb 1, 2014·Expert Opinion on Therapeutic Targets·Efthymia A Katsareli, George V Dedoussis
Jan 1, 2013·Medical Archives·Djordje BozovicNedeljka Ivkovic
Mar 20, 2014·Pain Management·Manon Ranger, Ruth E Grunau
Jun 11, 2014·PloS One·J Max GoodsonFrancine Welty
Dec 3, 2014·Immunology Letters·Massimo Costalonga, Mark C Herzberg
Dec 9, 2014·Frontiers in Pediatrics·Anjali IyengarJill L Maron
Dec 17, 2014·World Journal of Diabetes·Gauri S Desai, Suresh T Mathews
Jan 30, 2015·Autism Research : Official Journal of the International Society for Autism Research·Armand G Ngounou WetieAlisa G Woods
Mar 11, 2015·Clinical Therapeutics·Anjali Iyengar, Jill L Maron
Apr 9, 2015·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Cheryl S Rosenfeld
Dec 31, 2015·Molecular Oral Microbiology·E HajishengallisH Koo
Mar 24, 2016·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Richella RyanAngela Clow

❮ Previous
Next ❯

Citations

May 12, 2019·Oral Diseases·Joana L PereiraAna M Gil
Apr 15, 2020·Oral Diseases·Sarah F F GuedesLidiany K A Rodrigues
Mar 13, 2020·Metabolomics : Official Journal of the Metabolomic Society·Eric NeyraudCarole Tournier
Nov 4, 2020·Expert Review of Proteomics·Masahiro Sugimoto
Dec 6, 2020·Scientific Reports·Alexandra Gaál KovalčíkováPeter Celec
Jun 3, 2021·Brain Sciences·Monika FiguraAndrzej Friedman
Aug 4, 2021·Pediatric Research·Brittany K Wise-OringerAnne-Catrin Uhlemann
Mar 3, 2020·Neonatology·Abhijeet A RakshasbhuvankarJ Jane Pillow
Nov 12, 2021·Frontiers in Pediatrics·Nisreen KhambatiElse Margreet Bijker

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved