Saliva Iodine Concentration in Children and Its Association with Iodine Status and Thyroid Function.

The Journal of Clinical Endocrinology and Metabolism
Wenxing GuoWanqi Zhang

Abstract

The effectiveness of saliva iodine concentration (SIC) in evaluating iodine status in children is not clear. We aimed to explore associations between SIC and assessed indicators of iodine status and thyroid function. Cross-sectional study. Primary schools in Shandong, China. Local children aged 8 to 13 years with no known thyroid disease were recruited to this study. Blood, saliva, and urine samples were collected to evaluate thyroid function and iodine status. SIC positively correlated with spot urinary iodine concentration (r = 0.29, P < 0.0001), 24-hour urinary iodine concentration (r = 0.35, P < 0.0001), and 24-hour urinary iodine excretion (r = 0.40, P < 0.0001). The prevalence of thyroid nodules (TN) and goiter showed an upward trend with SIC quantiles (P for trend < 0.05). Children with SIC <105 μg/L had a higher risk of insufficient iodine status (OR = 4.18; 95% CI, 2.67-6.56) compared with those with higher SIC. Those having SIC >273 μg/L were associated with greater risks of TN (OR = 2.70; 95% CI, 1.38-5.26) and excessive iodine status (OR = 18.56; 95% CI, 5.66-60.91) than those with lower SIC values. There is a good correlation between SIC and urinary iodine concentrations. It is of significant reference value for th...Continue Reading

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Citations

Feb 16, 2021·Current Opinion in Clinical Nutrition and Metabolic Care·Delphine Ley, Dominique Turck
Jan 4, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Wenxing GuoWanqi Zhang
Sep 30, 2021·The Journal of Nutrition·Bernadette L DekkerAnneke C Muller Kobold

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