Saliva Pepsin Concentration of Laryngopharyngeal Reflux Patients Is Influenced by Meals Consumed Before the Samples

The Laryngoscope
Jerome R LechienSven Saussez

Abstract

To assess the impact of diet on the saliva pepsin concentration of patients with laryngopharyngeal reflux (LPR). Non-controlled Prospective Study. Patients with positive LPR regarding hypopharyngeal-esophageal impedance-pH monitoring (HEMII-pH) were enrolled from three European Hospitals. Patients collected three saliva samples, respectively, in the morning (fasting), and 1 to 2 hour after lunch and dinner. Patients carefully detailed foods and beverages consumed during meals and before the pepsin samples. The 3-month treatment was based on the association of diet, proton pump inhibitors, alginate, or magaldrate regarding the HEMII-pH characteristics. Reflux Symptom Score (RSS) and Reflux Sign Assessment (RSA) were used for assessing the pre- to posttreatment clinical evolution. The Refluxogenic Diet Score and the Refluxogenic Score of a Dish (RESDI) were used to assess the refluxogenic potential of foods and beverages. The relationship between saliva pepsin concentration, HEMII-pH, RESDI, RSS, and RSA was investigated through multiple linear regression. Forty-two patients were included. The saliva pepsin concentration of the 24-hour period of testing was significantly associated with foods and beverages consumed during the tes...Continue Reading

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Apr 16, 2019·The Laryngoscope·Jérôme R LechienSven Saussez
Aug 29, 2019·The Laryngoscope·Francois BobinJérôme R Lechien
Sep 14, 2019·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Jerome R LechienSven Saussez
Nov 5, 2019·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Jerome R LechienSven Saussez
Nov 16, 2019·The Annals of Otology, Rhinology, and Laryngology·Jérôme R LechienSven Saussez

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Citations

Dec 29, 2020·Medical Hypotheses·Jerome R LechienSven Saussez
Jul 14, 2021·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Jiasen WangRan Zhang

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