Saliva Proteomics Analysis Offers Insights on Type 1 Diabetes Pathology in a Pediatric Population

Frontiers in Physiology
Eftychia PappaKonstantinos Vougas

Abstract

The composition of the salivary proteome is affected by pathological conditions. We analyzed by high resolution mass spectrometry approaches saliva samples collected from children and adolescents with type 1 diabetes and healthy controls. The list of more than 2000 high confidence protein identifications constitutes a comprehensive characterization of the salivary proteome. Patients with good glycemic regulation and healthy individuals have comparable proteomic profiles. In contrast, a significant number of differentially expressed proteins were identified in the saliva of patients with poor glycemic regulation compared to patients with good glycemic control and healthy children. These proteins are involved in biological processes relevant to diabetic pathology such as endothelial damage and inflammation. Moreover, a putative preventive therapeutic approach was identified based on bioinformatic analysis of the deregulated salivary proteins. Thus, thorough characterization of saliva proteins in diabetic pediatric patients established a connection between molecular changes and disease pathology. This proteomic and bioinformatic approach highlights the potential of salivary diagnostics in diabetes pathology and opens the way for p...Continue Reading

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Citations

May 12, 2018·Oral Diseases·Eftychia PappaHeleni Vastardis
Jan 1, 2020·Journal of Biological Research·Katerina R Katsani, Dimitra Sakellari
Dec 5, 2020·Animals : an Open Access Journal From MDPI·Lorena Franco-MartínezAsta Tvarijonaviciute
Feb 16, 2021·Frontiers in Nutrition·Mathieu SchwartzFrancis Canon
Mar 9, 2019·Journal of Proteome Research·Yi-Han LinYanbao Yu
Oct 16, 2021·Comprehensive Reviews in Food Science and Food Safety·Mathieu SchwartzFrancis Canon

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Methods Mentioned

BETA
Protein Assay
blood collection

Software Mentioned

Ingenuity® Pathway Analysis
SIEMENS
Trans Proteomic Pipeline ( TPP )
R Core Team
Libra
R
ingenuity
L1000CDS
Skyline
QIAGEN

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