Salivaricin G32, a Homolog of the Prototype Streptococcus pyogenes Nisin-Like Lantibiotic SA-FF22, Produced by the Commensal Species Streptococcus salivarius.

International Journal of Microbiology
Philip A WescombeJohn R Tagg

Abstract

Salivaricin G32, a 2667 Da novel member of the SA-FF22 cluster of lantibiotics, has been purified and characterized from Streptococcus salivarius strain G32. The inhibitory peptide differs from the Streptococcus pyogenes-produced SA-FF22 in the absence of lysine in position 2. The salivaricin G32 locus was widely distributed in BLIS-producing S. salivarius, with 6 (23%) of 26 strains PCR-positive for the structural gene, slnA. As for most other lantibiotics produced by S. salivarius, the salivaricin G32 locus can be megaplasmid encoded. Another member of the SA-FF22 family was detected in two Streptococcus dysgalactiae of bovine origin, an observation supportive of widespread distribution of this lantibiotic within the genus Streptococcus. Since the inhibitory spectrum of salivaricin G32 includes Streptococcus pyogenes, its production by S. salivarius, either as a member of the normal oral microflora or as a commercial probiotic, could serve to enhance protection of the human host against S. pyogenes infection.

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Jul 28, 2006·Antonie van Leeuwenhoek·Philip A WescombeJohn R Tagg
Nov 7, 2006·Journal of Bacteriology·Christine DelormePierre Renault
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Citations

Sep 3, 2009·Future Microbiology·Philip A WescombeJohn R Tagg
Nov 12, 2013·International Journal of Medical Microbiology : IJMM·Jasmin DischingerGabriele Bierbaum
Jul 25, 2015·Science·Mohamed S Donia, Michael A Fischbach
Oct 15, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Christine DelormeEric Guédon
Oct 14, 2014·Frontiers in Cellular and Infection Microbiology·Juan Cristobal Jimenez, Michael J Federle
Aug 17, 2016·Scientific Reports·Abdelahhad BarbourKoshy Philip
Oct 12, 2017·Natural Product Reports·Walaa K MousaNathan A Magarvey
Aug 23, 2019·World Journal of Microbiology & Biotechnology·Vasundhera GuptaSuresh Korpole
Jan 5, 2021·World Journal of Microbiology & Biotechnology·Laura García-CurielNorberto Chavarría-Hernández
Oct 31, 2020·Frontiers in Microbiology·Cinthia Alves-BarrocoPedro Viana Baptista
Aug 7, 2021·Pathogens·Verena Vogel, Barbara Spellerberg
Oct 28, 2021·Microbiology Spectrum·Reed M StubbendieckCameron R Currie

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Datasets Mentioned

BETA
JN831266

Methods Mentioned

BETA
PCR
Electrophoresis

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