Salivary 8-OHdG: a useful biomarker for predicting severe ED and hypogonadism

The Journal of Sexual Medicine
Mitsuko YasudaShigeo Horie

Abstract

Erectile and endothelial dysfunction are common pathologies of multiple cardiovascular risk factors and are considered longitudinal predictors of cardiovascular events. Oxidative stress and decreases in testosterone levels play an important role in the pathogenesis of endothelial dysfunction. We sought to determine whether the severity of erectile dysfunction (ED) was associated with individual levels of testosterone and oxidative stress, and whether treatment with a phosphodiesterase type 5 inhibitor could reduce oxidative stress and increase testosterone availability. We evaluated the association of salivary 8-hydroxy-2'-deoxyguanosine (8-OHdG), salivary testosterone, International Index of Erectile Function-erectile function domain (IIEF-EF) scores, and Medical Outcome Study (MOS) 36-item Short-Form Healthy Survey (SF-36) questionnaires in 128 middle-aged male volunteers. We investigated the changes in testosterone levels, salivary 8-OHdG levels, IIEF-EF scores, and SF-36 scores in 20 ED patients (according to the IIEF-EF) who took 50 mg of sildenafil once a week for 6 months. IIEF-EF scores were used to assess ED severity. Antioxidant status was defined by salivary 8-OHdG. Salivary testosterone was used to evaluate serum bi...Continue Reading

References

Jan 1, 1997·Annual Review of Medicine·J P Cooke, V J Dzau
May 6, 1998·International Journal of Andrology·A BortolottiM Landoni
Oct 10, 1998·The American Journal of Psychiatry·H Sternbach
Mar 9, 1999·Journal of Cardiovascular Pharmacology·L T Dijkhorst-OeiT J Rabelink
Mar 23, 2000·Cardiovascular Research·J Y JeremyK M Naseem
Nov 14, 2000·Circulation Research·H Cai, D G Harrison
Feb 12, 2002·The Journal of Clinical Endocrinology and Metabolism·Henry A FeldmanJohn B McKinlay
Mar 26, 2002·The Journal of Urology·Ernani Luis RhodenCarlos Ary Vargas Souto
Oct 18, 2002·Journal of the American College of Cardiology·Julian P J HalcoxArshed A Quyyumi
Jun 30, 2004·International Journal of Impotence Research·A L Burnett
Aug 4, 2004·Psychoneuroendocrinology·Douglas A GrangerEve B Schwartz
Jan 1, 2005·Current Opinion in Urology·Piero MontorsiFrancesco Montorsi
Jul 12, 2005·Journal of Psychiatric Research·Masahiro IrieHiroshi Kasai
Sep 1, 2005·Cancer Science·Masahiro IrieHiroshi Kasai
Dec 13, 2005·Journal of Andrology·Ashok AgarwalRupesh Raina
Aug 24, 2006·The Journal of Clinical Endocrinology and Metabolism·Michael ZitzmannEberhard Nieschlag
Nov 9, 2006·The Journal of Clinical Endocrinology and Metabolism·William RosnerHershel Raff
Jun 27, 2007·Archives of Internal Medicine·Andre B AraujoJohn B McKinlay
Oct 24, 2007·Clinical Endocrinology·Alejandro L ArreggerEstela M L Cardoso

❮ Previous
Next ❯

Citations

Aug 26, 2015·International Journal of Urology : Official Journal of the Japanese Urological Association·Shin-ichi Hisasue
Apr 12, 2012·The Journal of Sexual Medicine·Masaki KimuraBridget F Koontz
Oct 27, 2015·International Journal of Urology : Official Journal of the Japanese Urological Association·Shin-ichi HisasueShigeo Horie
May 5, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Chiung-Wen HuMu-Rong Chao
Mar 13, 2014·Clinical Endocrinology·Koji ShiraishiHideyasu Matsuyama
May 30, 2013·Archives of Oral Biology·Tomoko KomatsuMasaichi-Chang-il Lee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.