Salivary alpha-synuclein in the diagnosis of Parkinson's disease and Progressive Supranuclear Palsy

Parkinsonism & Related Disorders
Giorgio VivacquaAlfredo Berardelli

Abstract

Alpha-synuclein (α-syn) aggregation is the pathological hallmark of Parkinson's Disease (PD). In this study, we measured α-syn total (α-syntotal), oligomeric α-syn (α-synolig) and α-synolig/α-syntotal ratio in the saliva of patients affected by PD and in age and sex-matched healthy subjects. We also compared salivary α-syntotal measured in PD with those detected in Progressive Supranuclear Palsy (PSP), in order to assess whether salivary α-syn can be used as a biomarker for PD and for the differential diagnosis between PD and PSP. We studied 100 PD patients, 20 patients affected by PSP and 80 age- and sex-matched healthy subjects. ELISA analysis was performed using two commercial ELISA platforms and a specific ELISA assay for α-syn aggregates. We detected lower α-syntotal and higher α-synolig in PD than in healthy subjects. Conversely in PSP salivary α-syntotal concentration was comparable to that measured in healthy subjects. Receiver Operating Characteristic analyses revealed specific cut-off values able to differentiate PD patients from healthy subjects and PSP patients with high sensitivity and specificity. However, there was no significant correlation between clinical and molecular data. Salivary α-syn detection could be a...Continue Reading

Citations

Jul 3, 2019·Journal of Neurochemistry·Muneera FayyadOmar M A El-Agnaf
Dec 5, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Marisa CressattiHyman M Schipper
Feb 6, 2020·Journal of Clinical Medicine·Patrick L McGeerEdith G McGeer
Apr 25, 2020·Brain Sciences·Giovanni SchepiciEmanuela Mazzon
Dec 14, 2019·Neurology and Therapy·Nicholas J AshtonKaj Blennow
Aug 12, 2019·Journal of Neural Transmission·Anastasia BougeaLeonidas Stefanis
Sep 12, 2020·Biomarker Insights·Elena CamporesiHenrik Zetterberg
Apr 22, 2021·Metabolic Brain Disease·Banabihari GiriChandramohan Wakade
May 12, 2021·Scientific Reports·Giorgio LeodoriAlfredo Berardelli
Jul 13, 2021·Journal of Parkinson's Disease·Manon AuffretMarc Vérin

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Alpha-Synuclein Aggregation (MDS)

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.