Salivary and serum procalcitonin and C-reactive protein as biomarkers of periodontitis in United States veterans with osteoarthritis or rheumatoid arthritis

Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission
R S RedmanE S Nylén

Abstract

Serum procalcitonin (ProCT) is elevated in response to bacterial infections, whereas high sensitivity C-reactive protein (hsCRP) is a nonspecific inflammatory marker that is increased by excess adipose tissue. We examined the efficacy of ProCT and hsCRP as biomarkers of periodontitis in the saliva and serum of patients with arthritis, which is characterized by variable levels of systemic inflammation that potentially can confound the interpretation of inflammatory biomarkers. Blood and unstimulated whole saliva were collected from 33 patients with rheumatoid arthritis (RA) and 50 with osteoarthritis (OA). Periodontal status was assessed by full mouth examination and patients were categorized as having no/mild, moderate or severe periodontitis by standard parameters. Salivary and serum ProCT and hsCRP concentrations were compared. BMI, diabetes, anti-inflammatory medications and smoking status were ascertained from the patient records. Differences between OA and RA in proportionate numbers of patients were compared for race, gender, diabetes, adiposity and smoking status. Serum ProCT was significantly higher in arthritis patients with moderate to severe and severe periodontitis compared with no/mild periodontitis patients. There...Continue Reading

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Citations

Sep 12, 2019·Journal of Applied Oral Science : Revista FOB·Jackeline do Nascimento TsurumakiRosemary Adriana Chiérici Marcantonio
May 10, 2020·Periodontology 2000·Peter Mark Bartold, Isabel Lopez-Oliva
Aug 20, 2019·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·R S RedmanE S Nylén
Oct 30, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Priya DesaiJoon Young Kim
Apr 15, 2021·Critical Reviews in Clinical Laboratory Sciences·Christophe HirtzRui Vitorino

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