Salivary apoptotic cells in oral (pre-) cancer as a potential diagnostic means

Journal of Clinical and Experimental Dentistry
Jasdeep KaurReinhilde Jacobs

Abstract

Apoptosis is a genetically programmed form of cell death which is indispensable for development and homeostasis of multi-cellular organism. The aim of this study was to find out the salivary apoptotic cells in oral precancerous and cancerous patients and furthermore to observe the potential diagnostic value of salivary apoptotic cells in detection of oral pre-cancer and cancer. Unsimulated saliva was collected from a group of 103 subjects diagnosed with oral (pre-)cancer and a control group of 30 healthy age- and gender-matched individuals. The test group diagnosed with (pre-)cancer was further subdivided in 4 lesion groups oral squamous cell carcinoma (OSCC), oral lichen planus lesions (n=26), oral leukoplakia (n=25), oral sub-mucous fibrosis (n=24) Apoptotic cells were morphologically studied using fluorescence microscopy (TUNEL technique). While the morphology of apoptotic cells in oral pre-cancer and cancer are morphological similar to the typical epithelial cells of oral cavity mucosa, the number of apoptotic cells was significantly less in OSCC as compared to precancerous and normal healthy tissues. It could therefore be concluded that salivary apoptotic epithelial cells might be used in early detection and diagnosis of o...Continue Reading

Citations

Apr 24, 2018·Disease Markers·Mircea TampaSimona-Roxana Georgescu
May 23, 2021·Archives of Oral Biology·Narges Ghazi, Maryam Khorasanchi

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Software Mentioned

VELScope
Identafietc

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Farzaneh Agha-HosseiniMohammad Abdollahi
© 2021 Meta ULC. All rights reserved