Salivary, blood and plasma nitrite concentrations in periodontal patients and healthy individuals before and after periodontal treatment

Clinica Chimica Acta; International Journal of Clinical Chemistry
Cesar A MeschiariAndrea M Marcaccini

Abstract

To date, no study has employed ozone-based reductive chemiluminescence to compare nitrite concentration in the saliva of periodontal disease (PD) and healthy individuals or in the various blood compartments of the same individuals before and after periodontal treatment. We evaluated nitrite concentrations in whole, submandibular, and parotid saliva, as well as in whole blood, erythrocytes, and plasma of healthy volunteers and patients with chronic periodontitis. Data obtained for the PD and control groups were compared before and 3 months after periodontal therapy. At baseline, stimulated whole saliva nitrite concentration was lower in PD patients (mean=57.3 ± 9.8 μmol/L) as compared with healthy individuals (92.5 ± 13.6 μmol/L, P<0.05). PD and periodontal treatment did not affect submandibular or parotid saliva nitrite concentrations. PD patients presented higher baseline whole blood nitrite concentration (238.4 ± 45.7 μmol/L) as compared with values recorded 3 months after therapy (141.3 ± 20.1 nmol/L, P<0.05). PD patients' erythrocytes exhibited higher baseline nitrite concentration (573.1 ± 97.8 nmol/L) as compared with three months after therapy (298.7 ± 52.1 nmol/L, P<0.05). Again, PD and PD treatment did not impact plasm...Continue Reading

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Citations

Dec 19, 2015·Expert Review of Molecular Diagnostics·Jason TasoulasStamatios Theocharis
Aug 16, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jianxing Zhao, Ying Huang
Jun 16, 2017·International Journal of Molecular Sciences·Raquel M Scarel-CaminagaJoni A Cirelli
Nov 6, 2015·Frontiers in Cellular and Infection Microbiology·L'ubomíra TóthováPeter Celec

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