Salivary cortisol and cortisone responses to tetracosactrin (synacthen)

Annals of Clinical Biochemistry
M P CornesRousseau Gama

Abstract

To establish cutoff values for salivary liquid chromatography tandem mass spectroscopy cortisol and cortisone in defining adequate adrenocortical function during a standard synacthen test. We compared salivary liquid chromatography tandem mass spectroscopy cortisol and cortisone responses to those of serum cortisol measured on the Roche E170 immunoassay analyser and the Abbott Architect i2000 before and 30 min and 60 min following 0.25 mg of intravenous synacthen. Correlations of salivary cortisol and cortisone were bimodal and linear, respectively. Based on these correlations, adequate salivary cortisol and cortisone responses to synacthen were extrapolated from a serum cortisol (Roche) cut-off of 550 nmol/L and defined as 15 nmol/L and 45 nmol/L, respectively. The Abbott method correlated well with the Roche but gave results that were about 20% lower than the Roche method. Measurement of salivary cortisol and cortisone responses offers an alternative to those of serum cortisol during a synacthen test in the investigation of adrenal hypofunction.

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Citations

Oct 10, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Giorgia AntonelliMario Plebani
May 2, 2016·Clinical Biochemistry·Brian G Keevil
May 22, 2016·The Journal of Steroid Biochemistry and Molecular Biology·James M Hawley, Brian G Keevil
Aug 24, 2016·The World Allergy Organization Journal·Elham HossnyPeter Le Souef
Apr 5, 2017·Current Opinion in Endocrinology, Diabetes, and Obesity·Joanne BlairRichard Ross
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Mar 21, 2016·Prague Medical Report·Michaela DuškováLuboslav Stárka
Dec 22, 2017·Journal of the Endocrine Society·Ingrid Yin Fung MakSau Cheung Tiu
Nov 19, 2019·Current Pediatric Reviews·Nese Akcan, Nerin N Bahceciler
May 23, 2017·Endocrine·Leonard SaieghCarmela Shechner
Nov 7, 2017·Clinical Endocrinology·Charlotte J ElderRichard J Ross
Jul 20, 2019·International Journal of Endocrinology·Lara AlbertOlga Giménez-Palop
Sep 29, 2020·Endocrinology and Metabolism·Yoon Ji KimSeong Yeon Kim

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