Salivary cortisol results obtainable within minutes of sample collection correspond with traditional immunoassays

Clinical Therapeutics
E A ShirtcliffPaul D Slowey

Abstract

Cortisol is frequently assayed as a stress-responsive biomarker which changes over the course of minutes to meet the demands of a person's social context. Salivary cortisol is often used as a noninvasive sampling method that possesses important health implications. A critical barrier to psychobiological research that involves salivary cortisol is a time delay of days to months before cortisol results are obtained via immunoassay, long after the person is no longer proximate to the social context in which they provided the sample. The present study was designed to address this critical barrier through creation of a lateral flow test (LFT) cortisol device capable of measuring salivary cortisol within minutes of sample collection. The LFT is frequently used within commercial point-of-care settings to obtain rapid answers to the presence/absence of a biomarker. The present study extends the LFT into the research domain by presenting performance characteristics of a quantitative LFT that measures salivary cortisol within 20 minutes of sample collection. Saliva samples from 29 adults (15 men) were obtained in the morning and afternoon by using Passive Drool and then the Super·SAL Extra Collection Device (hereafter Super·SAL) and late...Continue Reading

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Citations

Mar 10, 2015·Clinical Therapeutics·Richard I Shader
Mar 10, 2015·Clinical Therapeutics·Jill L Maron
Jun 9, 2016·International Journal of Molecular Sciences·Zohaib KhurshidKhalid Almas
May 12, 2018·Oral Diseases·Eftychia PappaHeleni Vastardis
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Dec 4, 2019·Scientific Reports·Maria Fernanda Marques Silva de CarvalhoLuciana Marti
Jan 7, 2021·ACS Omega·Shima DaliriradAndrew J Steckl

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