Salivary Cytoprotective Proteins in Inflammation and Resolution during Experimental Gingivitis-A Pilot Study

Frontiers in Cellular and Infection Microbiology
Guy M AboodiMichael Glogauer

Abstract

The protective mechanisms that maintain periodontal homeostasis in gingivitis and prevent periodontal tissue destruction are poorly understood. The aim of this study was to identify changes in the salivary proteome during experimental gingivitis. We used oral neutrophil quantification and whole saliva (WS) proteomics to assess changes that occur in the inflammatory and resolution phases of gingivitis in healthy individuals. Oral neutrophils and WS samples were collected and clinical parameters measured on days 0, 7, 14, 21, 28, and 35. Increased oral neutrophil recruitment and salivary cytoprotective proteins increased progressively during inflammation and decreased in resolution. Oral neutrophil numbers in gingival inflammation and resolution correlated moderately with salivary β-globin, thioredoxin, and albumin and strongly with collagen alpha-1 and G-protein coupled receptor 98. Our results indicate that changes in salivary cytoprotective proteins in gingivitis are associated with a similar trend in oral neutrophil recruitment and clinical parameters. We found moderate to strong correlations between oral neutrophil numbers and levels of several salivary cytoprotective proteins both in the development of the inflammation and ...Continue Reading

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Citations

Oct 5, 2018·International Endodontic Journal·P A FranciscoB P F A Gomes
Feb 6, 2020·Briefings in Bioinformatics·Lan HuangJuan Cui
Oct 20, 2020·Frontiers in Immunology·Noah FineMichael Glogauer
Oct 14, 2021·Database : the Journal of Biological Databases and Curation·Dan ShaoJuan Cui

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Methods Mentioned

BETA
fluorescence microscopy

Software Mentioned

Proteome Discoverer
JMP
SIEVE

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