Salivary Del-1, IL-17, and LFA-1 levels in periodontal health and disease

Journal of Periodontal Research
Elif InönüSema S Hakki

Abstract

Developmental endothelial locus-1 (Del-1), lymphocyte function-associated antigen-1 (LFA-1), and interleukin 17 (IL-17) play critical roles in transendothelial migration of neutrophils in periodontal diseases. The aim of this study was to evaluate salivary Del-1, IL-17, and LFA-1 protein levels in patients with gingivitis (G), chronic periodontitis (CP), and generalized aggressive periodontitis (GAP). A total of 180 systemically healthy, non-smoking patients (45 periodontally healthy (H) and 45 G, 50 CP, and 40 GAP) individuals (between March 2014 and February 2016) were included in this study according to Armitage's (1999) classification. Clinical periodontal parameters, including clinical attachment level, probing depth, plaque index, and gingival index, were recorded. Del-1, IL-17, and LFA-1 protein expression levels were measured in unstimulated saliva samples collected from patients by using enzyme-linked immunosorbent assays. Kruskal-Wallis and Mann-Whitney U tests were used for multiple comparisons and post hoc statistical analyses, respectively. ROC curve analysis was used to evaluate the sensitivity and specificity of Del-1, IL-17, and LFA-1 in distinguishing periodontal disease from health and gingivitis. It was found...Continue Reading

References

Nov 1, 1967·Journal of Periodontology·H Löe
Oct 1, 1994·Oral Microbiology and Immunology·S AgarwalM B Aichelmann-Reidy
Jun 23, 2000·Annals of Periodontology·G C Armitage
Feb 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Erik LubbertsWim B van den Berg
Apr 7, 2005·Journal of Clinical Periodontology·Keiso TakahashiShin Kitetsu
Apr 17, 2007·Annals of the New York Academy of Sciences·Janet S KinneyWilliam V Giannobile
Aug 25, 2007·Nature Reviews. Immunology·Klaus LeySussan Nourshargh
Apr 25, 2009·Periodontology 2000·William V GiannobileDavid T Wong
Aug 27, 2010·Journal of Dental Research·J A LooD T Wong
Sep 3, 2010·Journal of Periodontology·Patrícia Maria A LimaWalderez Ornelas Dutra
Dec 25, 2010·Brazilian Dental Journal·Crésio AlvesRafaela Menezes
Mar 27, 2012·Nature Immunology·Mehmet A EskanGeorge Hajishengallis
Jan 15, 2014·Clinical & Developmental Immunology·Jieun ShinGeorge Hajishengallis
Nov 2, 2014·Journal of Clinical Periodontology·Helen M RobertsIain L C Chapple
Mar 20, 2015·Journal of Periodontology·Serhat KöseoğluRecep Sütçü
Mar 27, 2015·Journal of Indian Society of Periodontology·Muthugounder Nalanaswamy ChitrapriyaVamsi Lavu
Jul 30, 2015·Journal of Applied Oral Science : Revista FOB·Nora SilvaJorge Gamonal
Oct 2, 2015·Science Translational Medicine·Jieun ShinGeorge Hajishengallis
Dec 15, 2015·Periodontology 2000·Dina L Korte, Janet Kinney
Dec 15, 2015·Periodontology 2000·Xiaoli GaoChin-Ying Stephen Hsu
Dec 15, 2015·Periodontology 2000·Katrin M JaedickeJohn J Taylor
Feb 9, 2016·Archives of Oral Biology·Diana M Isaza-GuzmánSergio I Tobón-Arroyave
Mar 5, 2016·Seminars in Immunology·George HajishengallisTriantafyllos Chavakis
Mar 5, 2016·Journal of Oral Biology and Craniofacial Research·Mohammad A JavaidSimon D Tran
Mar 30, 2018·American Journal of Speech-language Pathology·Charles R GreenwoodJudith J Carta
Nov 21, 2018·Nature Immunology·Ioannis KourtzelisTriantafyllos Chavakis

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Citations

Apr 20, 2021·Expert Review of Clinical Immunology·George Hajishengallis, Triantafyllos Chavakis
May 25, 2021·Journal of Leukocyte Biology·Wenzhe WangBei Li

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