Salivary duct carcinoma: a Danish national study

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Helle BreinholtKristine Bjørndal

Abstract

To present the first national series of salivary duct carcinoma patients, including survival rates and an analysis of prognostic factors. By merging three Danish nationwide registries that encompass an entire population, 34 patients diagnosed with salivary duct carcinoma from 1990 to 2005 were identified. Histological slides were reviewed, and data concerning demographics, tumour site, clinical stage, treatment profiles and follow-up were retrieved. Survival estimates and prognostic factors were evaluated by comparing Kaplan-Meier plots using the Mantel-Haenszel log-rank test. Salivary duct carcinoma showed an incidence of 0.04/100.000 inhabitants/year. Distant recurrence was seen in 52% of patients. Five-year overall survival, disease-specific survival and recurrence-free survival were 32%, 42% and 35%, respectively. Univariate analyses suggested that overall stage (III/IV) and vascular invasion have a negative impact on all survival measures. Involved resection margins correlated with a poorer overall survival and disease-specific survival, whereas adjuvant radiotherapy improved overall survival and recurrence-free survival. Salivary duct carcinoma incidence averages to two episodes per year in the entire Kingdom of Denmark. ...Continue Reading

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Citations

Jan 27, 2018·Current Opinion in Otolaryngology & Head and Neck Surgery·Emmanuel D'heygereVincent Vander Poorten
May 23, 2018·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Ann-Jean C C BeckWillem M C Klop
Dec 24, 2019·International Journal of Oral and Maxillofacial Surgery·Y M ParkE C Choi

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