Salivary enzyme activity in anorexic persons—a controlled clinical trial

Clinical Oral Investigations
Elzbieta PaszyńskaC Hannig

Abstract

Patients with anorexia nervosa are at high risk for general and oral diseases. However, not all anorexic patients suffer from them, irrespective of the severity of their eating disorder. It is often speculated that differences in the saliva are important; however, little is known about salivary parameters in anorexic patients. The aim of the clinical trial was to evaluate stimulated and resting salivary flow rate and the activity of the following enzymes in both types of saliva: amylase, aspartate amino transferase (AST), alanine amino transferase (ALT), collagenase, lysozyme, peroxidase, serine and acidic proteases, and trypsin in persons with anorexia nervosa (AN) and to compare them with those of healthy controls. Sixty-six subjects participated (28 patients with anorexia nervosa, 38 matched healthy controls). Regarding flow rate, stimulated and unstimulated levels were significantly lower in the AN group than in the controls. Activities of collagenase and AST in stimulated saliva were significantly higher in anorexic participants. In the AN group, changes due to salivary stimulation were found for the activity of acidic proteases, AST, and lysozyme. Reduced salivary flow might be one indicator of anorexia. Despite starvatio...Continue Reading

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Citations

Apr 14, 2015·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Elzbieta PaszynskaAndrzej Rajewski
Mar 17, 2016·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·E PaszynskaA Slopien
Mar 19, 2019·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Elzbieta PaszynskaMonika Dmitrzak-Weglarz
Feb 16, 2018·Clinical Oral Investigations·Elzbieta PaszynskaTeresa Grzelak
Sep 1, 2021·Periodontology 2000·Hélène RangéPhilippe Bouchard

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