Salivary exosomes: properties, medical applications, and isolation methods.

Molecular Biology Reports
Behzad Cheshmi, Hamid Cheshomi

Abstract

Salivary exosomes are extracellular vesicles (EVs) with abundant CD63 immunoreactivity on their surface. Based on their size and protein composition, these exosomes can be categorized into two classes of exosomes I (mean diameter of 83.5 nm) and II (mean diameter of 40.5 nm). We have attempted to review the features of these exosomes, including origin, composition, separation methods, and their application in medicine. Not only the composition of salivary exosomes is invaluable in term of diagnosis, but can also afford an understanding in roles of the contents and components of these exosomes in the fundamental pathophysiologic processes of different diseases. since these EVs can cross the epithelial barriers they may be essential for transporting of multifarious components from the blood into saliva. Thus, in comparison to other bodily fluids, salivary exosomes are probably a better and accessible tool to examine the function of exosomes in the diagnosis and treatment of disease.

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Citations

Apr 23, 2021·Advanced Drug Delivery Reviews·Alice GualerziMarzia Bedoni
Jul 31, 2021·Cancer Management and Research·Yongqin DengDong Ye

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Methods Mentioned

BETA
deubiquitination
GTPases
ubiquitination
chips

Software Mentioned

ExoCarta
EVpedia
Vesiclepedia

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