Salivary fingerprint of simple obesity

Cytokine
Anna Lehmann-KalataJ Witowski

Abstract

The nature of a link between poor oral health and obesity is not fully understood. It is also unclear if saliva contributes to it and whether the properties of saliva change as a result of an increase in body mass or rather as a consequence of obesity-associated comorbidities. This pilot study was undertaken in an attempt to determine if salivary biomarkers can identify obesity per se. Whole mixed saliva was analysed for 16 soluble parameters covering 4 categories (inflammation, oxidative stress, endothelial dysfunction, adipokines). In the discovery group, 19 obese and 25 non-obese women matched for age, with similar hygiene habits, with no comorbidities and not taking any medication known to affect saliva secretion were analysed. In the validation group, a cohort of no-preselected 81 individuals (34 obese) were analysed. Individuals with obesity had significantly higher salivary concentrations of several cytokines and adipokines, of which TNF-R1, serpin A12 and PAI-1 were identified as parameters discriminating between obese and non-obese subjects with the highest sensitivity and specificity. Obesity per se leads to distinct changes in the concentration of several parameters in saliva. These findings may have diagnostic impli...Continue Reading

Citations

Dec 19, 2018·Journal of Texture Studies·Bárbara de Lima LucasMaria Beatriz Duarte Gavião
Jul 1, 2020·PloS One·Lucyna OstrowskaAnna Bielawska
Oct 20, 2018·International Journal of Molecular Sciences·Akiko Suzuki, Junichi Iwata
Sep 5, 2019·Journal of Evidence-based Medicine·Letícia Fernanda DufflesTarcília Aparecida Silva
Dec 11, 2019·Journal of Clinical Medicine·Sanna SyrjäläinenEija Könönen
Sep 3, 2020·International Journal of Environmental Research and Public Health·Kacper NijakowskiAnna Surdacka
Apr 27, 2021·Oxidative Medicine and Cellular Longevity·Mateusz MaciejczykKarolina Gerreth
Aug 27, 2021·Scientific Reports·Mateusz MaciejczykKarolina Gerreth

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