Salivary flow rate and biochemical composition analysis in stimulated whole saliva of children with cystic fibrosis

Archives of Oral Biology
Karine Barros da Silva ModestoEliete Rodrigues de Almeida

Abstract

It is recognized that cystic fibrosis (CF) patients present a risk for oral diseases, since it affects exocrine glands, and the treatment consists of a carbohydrate-rich diet. Recognizing the protective function of saliva on maintaining oral health, the aim of the study was to evaluate salivary parameters in stimulated whole saliva from children with CF. A case-control study was conducted comparing stimulated whole saliva of healthy (n=28; control group) and CF children (n=21; experimental group). Salivary flow rate, initial pH, buffer capacity (total and in each range of pH), total protein and sialic acid (total, free, and conjugated) concentration, α-amylase and salivary peroxidase activities were evaluated. Data were compared by two-tailed Student t test (95% CI; p ≤ 0.05). CF patients presented a significant reduction in salivary parameters compared with the control group (p ≤ 0.05): salivary flow rate (36%), buffer capacity (pH range from 6.9 to 6.0), sialic acid concentration (total 75%, free 61%, and conjugated 83%); α-amylase and salivary peroxidase activities (55%). Additionally, a significant increase in total protein concentration (180%) of stimulated whole saliva from CF patients was verified compared with the contr...Continue Reading

References

Jan 15, 1979·Molecular and Cellular Biochemistry·A HerpJ Moschera
Jan 1, 1986·Archives of Oral Biology·L C Anderson
Jun 28, 1996·The Journal of Biological Chemistry·O SeksekA S Verkman
Aug 23, 2002·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·T VuotilaL Tjäderhane
Nov 28, 2002·Journal of Dental Research·Jorma Tenovuo
Jul 24, 2003·Archives of Disease in Childhood·A NarangA Bush
Mar 9, 2005·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Eitan KeremUNKNOWN Consensus Committee
Aug 23, 2005·Archives of Biochemistry and Biophysics·Riikka IhalinJorma Tenovuo
Nov 4, 2006·American Journal of Respiratory and Critical Care Medicine·Patryk MoskwaBotond Bánfi
Dec 13, 2006·Autonomic Neuroscience : Basic & Clinical·Gordon B Proctor, Guy H Carpenter
Dec 22, 2006·The European Respiratory Journal·J A DodgeJ Wilsher
Sep 4, 2007·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Sabrina NoëlFrédéric Becq
Jun 4, 2008·Folia Histochemica Et Cytobiologica·Łukasz MinarowskiElzbieta Chyczewska
Jul 12, 2011·Molecular Immunology·Seulggie ChoiSeung Hyun Han
Sep 21, 2011·PloS One·Mathilde RottnerMaría Carmen Martínez
Aug 1, 2012·The American Journal of Pathology·Christophe DurantonMichel Tauc
Jul 1, 2010·Indian Journal of Medical Sciences·T Deepa, N Thirrunavukkarasu
Mar 21, 2013·Diagnostic Pathology·Aline Cristina GonçalvesCarlos Emílio Levy
Jun 19, 2013·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Karoline Droebner, Peter Sandner
Oct 8, 2013·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Jane L Burns, Jean-Marc Rolain
Dec 18, 2013·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Alice Rodrigues Feres de MeloMariana Ferreira Leite
Feb 15, 2014·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Graham DevereuxDouglas Miller
Oct 1, 2014·PloS One·Ludovic JeansonAleksander Edelman

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Citations

Jun 15, 2017·Revista da Associação Médica Brasileira·Kadriye Görkem Ulu GüzelMünciye Semra Özay Ertürk
Sep 7, 2019·Journal of Oral Microbiology·Rebeca Passarelli MantovaniCaterina Signoretto
Nov 27, 2018·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Tamara Pawlaczyk-KamieńskaSzczepan Cofta

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