Salivary Gland Dysplasia in Fgf10 Heterozygous Mice: A New Mouse Model of Xerostomia

Current Molecular Medicine
A J MayA S Tucker

Abstract

Xerostomia, or chronic dry mouth, is a common syndrome caused by a lack of saliva that can lead to severe eating difficulties, dental caries and oral candida infections. The prevalence of xerostomia increases with age and affects approximately 30% of people aged 65 or older. Given the large numbers of sufferers, and the potential increase in incidence given our aging population, it is important to understand the complex mechanisms that drive hyposalivation and the consequences for the dentition and oral mucosa. From this study we propose the Fgf10 +/- mouse as a model to investigate xerostomia. By following embryonic salivary gland development, in vivo and in vitro, we show that a reduction in Fgf10 causes a delay in branching of salivary glands. This leads to hypoplasia of the glands, a phenotype that is not rescued postnatally or by adulthood in both male and female Fgf10 +/- mice. Histological analysis of the glands showed no obvious defect in cellular differentiation or acini/ductal arrangements, however there was a significant reduction in their size and weight. Analysis of saliva secretion showed that hypoplasia of the glands led to a significant reduction in saliva production in Fgf10 +/- adults, giving rise to a reduced...Continue Reading

Citations

Nov 9, 2016·Frontiers in Physiology·Tathyane H N TeshimaAbigail S Tucker
Sep 27, 2018·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Kojiro YamajiTatsuo Kawamoto
Dec 7, 2018·Frontiers in Genetics·Michaela ProchazkovaOphir D Klein
Dec 29, 2020·Frontiers in Cell and Developmental Biology·Yang ZhangAbigail S Tucker
Jan 16, 2021·Cellular and Molecular Life Sciences : CMLS·Akiko SuzukiJunichi Iwata
Jan 18, 2021·Journal of Anatomy·Lemonia ChatzeliAbigail S Tucker
May 11, 2021·European Journal of Human Genetics : EJHG·Emma M WadeTim Cundy

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