Salivary gland epithelial cells (SGEC): carriers of exquisite B7-2 (CD86) costimulatory molecules

Journal of Autoimmunity
E K Kapsogeorgou, M N Manoussakis

Abstract

Costimulatory molecules are cell-surface glycoproteins that can direct, modulate and fine tune immune responses. B7-2(CD86) costimulatory molecules are considered as major regulators of T cell responses, acting by appropriate interactions with the stimulatory CD28 or inhibitory CTLA-4 receptors found on T cells. Although their expression is thought to be restricted in lymphoid cells, evidence raised during the last decade show their expression in other types of cells, including human non-neoplastic salivary gland epithelial cells (SGEC). The expression of B7-2 molecules by SGECs requires special attention, due to their unique expression pattern and distinctive binding properties. Thus, SGECs express three B7-2 alternate transcripts that encode the full-length protein, the soluble form and a truncated membrane-bound molecule, that lacks the IgV-like counter-receptor binding domain and has a negative regulatory role. A similar pattern of expression is observed in monocytes, but not in several other types of cells, including dendritic cells. Furthermore, the full-length B7-2 molecules in SGEC display unique binding properties, denoted by the functional interaction with CD28 receptor, but reduced binding of the negative regulator C...Continue Reading

References

Nov 4, 1993·Nature·M AzumaC Somoza
Jan 1, 1996·Annual Review of Immunology·D J LenschowJ A Bluestone
Dec 1, 2001·The Journal of Biological Chemistry·Susmit SuvasJaved N Agrewala
Mar 26, 2002·Nature Reviews. Immunology·Arlene H Sharpe, Gordon J Freeman
Aug 28, 2002·Immunity·Alison V CollinsSimon J Davis
Oct 10, 2002·Nephron·Ulrike Niemann-MasanekFokko J van der Woude
May 2, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Qiong WuHideto Sakai
Sep 11, 2004·Immunity·Tsvetelina Pentcheva-HoangJames P Allison
Mar 18, 2005·Annual Review of Immunology·Rebecca J GreenwaldArlene H Sharpe
Mar 26, 2005·Immunological Reviews·Mary E Keir, Arlene H Sharpe
Nov 10, 2007·Clinical Reviews in Allergy & Immunology·Menelaos N Manoussakis, Efstathia K Kapsogeorgou
Jan 15, 2008·Autoimmunity Reviews·M Eric Gershwin
May 27, 2008·Journal of Autoimmunity·Senga WhittinghamM Eric Gershwin
Sep 2, 2008·Immunological Reviews·Brian T Fife, Jeffrey A Bluestone
Nov 7, 2008·Trends in Molecular Medicine·Barbara SeligerHinrich Abken
Aug 18, 2009·Journal of Autoimmunity·Aftab A Ansari, M Eric Gershwin
Aug 6, 2010·Journal of Autoimmunity·Menelaos N Manoussakis, Efstathia K Kapsogeorgou

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Citations

Mar 1, 2012·Journal of Autoimmunity·A G Tzioufas, P G Vlachoyiannopoulos
Dec 18, 2013·Journal of Autoimmunity·Nikolaos C KyriakidisAthanasios G Tzioufas
Jan 15, 2014·Journal of Autoimmunity·Ya-Zhuo GongJacques-Eric Gottenberg
Jul 23, 2013·Biochemical and Biophysical Research Communications·M A Romero-TlaloliniEfraín Garrido
Feb 22, 2017·International Journal of Rheumatic Diseases·Xiaomei LiYiping Wang
Jan 22, 2021·Autoimmunity Reviews·Muhammad S Soyfoo, Charles Nicaise
Aug 6, 2010·Journal of Autoimmunity·Menelaos N Manoussakis, Efstathia K Kapsogeorgou

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