PMID: 9130989Apr 1, 1997Paper

Salivary gland-like tumors of the sellar region

The American Journal of Surgical Pathology
T A HamptonP Vogt

Abstract

Herein we present a group of rare tumors of the sella region that have not been previously recognized. Although clinically and radiographically the tumors resemble nonfunctioning pituitary adenomas, their histologic, immunohistochemical, and ultrastructural features differ and indicate a salivary gland origin. The lesions cover a morphologic spectrum that includes cellular pleomorphic adenoma, monomorphic adenoma, oncocytoma, and low-grade adenocarcinoma of the salivary gland. All tumors except the oncocytoma were immunoreactive for cytokeratin and were negative for pituitary hormones and synaptophysin. Ultrastructural characteristics in the cases examined include hypodense stromal material, basal lamina, and tonofilament bundles. The single oncocytoma was packed with mitochondria and lacked membrane-bound secretory granules. DNA ploidy based on image analysis and MIB-1 labeling indices showed diversity within this group of tumors, with labeling indices ranging from 0.06% to 15%. The presumed origin of these rare neoplasms is from salivary gland rests related to the normal pituitary gland. Despite their varied morphology, such tumors are easily confused with pituitary adenoma. Although rare, tumors of salivary gland origin shou...Continue Reading

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Citations

Aug 10, 2002·The American Journal of Surgical Pathology·Federico RoncaroliAllan J Yates
Jan 7, 2004·The American Journal of Surgical Pathology·Fausto RodriguezCaterina Giannini
Aug 17, 2010·The American Journal of Dermatopathology·Dmitry V KazakovMichal Michal
Apr 27, 2007·The American Journal of Surgical Pathology·Sibel ErdoganMichael Rabin
Jun 27, 2007·The American Journal of Surgical Pathology·Fausto J RodriguezDavid G Piepgras
Aug 30, 2008·The American Journal of Surgical Pathology·Martin HasselblattWerner Paulus
Sep 28, 2010·The American Journal of Surgical Pathology·Boris RychlyMichal Michal
Feb 27, 2007·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Marion Rittierodt, Akira Hori
Aug 12, 2006·Endocrine Journal·Takakazu KawamataTomokatsu Hori
Apr 18, 2014·Indian Journal of Pathology & Microbiology·Kun YaoXueling Qi
May 26, 2007·Journal of the Chinese Medical Association : JCMA·Chih-Hao ChenYu-Shing Lo
Jul 29, 2016·World Neurosurgery·Liqun YangRumal Jayalath
Dec 8, 2010·Neurosurgery·Satoshi TakahashiTakeshi Kawase
Oct 30, 2015·International Journal of Surgical Pathology·Bonnie Choy, Peter Pytel
Nov 21, 2019·Neurology India·G GowripriyaMukul Vij
Jan 5, 2020·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Victoria LavinFederico Roncaroli
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Jan 6, 2021·Head and Neck Pathology·Kiyohiko SakataMotohiro Morioka
Aug 25, 2001·Archives of Pathology & Laboratory Medicine·C E FullerR Schelper

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