Salivary gland-type tumors with myoepithelial differentiation arising in pulmonary hamartoma: report of 2 cases of a hitherto unrecognized association

The American Journal of Surgical Pathology
Giuseppe PelosiJuan Rosai

Abstract

Reported is a hitherto unrecognized association of pulmonary hamartomas with salivary gland-type tumors showing myoepithelial differentiation, namely, a case of myoepithelioma arising in a otherwise classic hamartoma with cartilage predominance, and a case of malignant mixed tumor arising in a predominantly fibrous hamartoma resembling müllerian adenofibroma. The tumors occurred in middle-aged female patients of 35 and 44 years, respectively, and presented as 7 cm (treated with lobectomy) and 13 cm (treated with pneumonectomy) masses of the right upper lobe showing a short clinical history of cough, dyspnea, and wheezing. Both lesions did not present regional lymph node metastases after mediastinal lymphadenectomy. The myoepithelioma patient was well with no signs of recurrent disease at 6-month clinical control, but she was then lost to follow-up; the malignant mixed tumor patient is alive and well after 6 months since operation. Both tumors presented with morphologic and immunohistochemical features of myoepithelial cells, and we interpret them as being derived from a myoepithelial-like stromal cell population found within the hamartomatous areas, which is also consistently detected in classic pulmonary hamartoma. The lack of...Continue Reading

Citations

Apr 2, 2010·Head & Neck Oncology·Juan RenYuan Liu
May 13, 2010·International Journal of Surgical Pathology·Giuseppe PelosiGiuseppe Viale
Nov 10, 2007·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Michael ThrallStefan E Pambuccian
Jul 11, 2018·Surgical Case Reports·Yasuhiro NakashimaTakuya Yazawa
Jul 28, 2020·International Journal of Surgical Pathology·Giulio RossiThomas Colby
Dec 10, 2015·The American Journal of Surgical Pathology·Charles LeducWilliam D Travis
Apr 7, 2007·The American Journal of Surgical Pathology·Tiffany ChangThomas Krausz

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