Salivary gland ultrasonography as a primary imaging tool for predicting efficacy of xerostomia treatment in patients with Sjögren's syndrome

Rheumatology
Yukinori TakagiTakashi Nakamura

Abstract

To evaluate ultrasonography (US) grading of salivary gland disease as a predictor of treatment efficacy for impaired salivary function in xerostomia patients with or without Sjögren's syndrome (SS). We retrospectively analysed the prognostic importance of salivary US grading in 317 patients (168 with SS and 149 without SS). US images of the parotid and submandibular glands in each patient were individually categorized into grades 0-4 based on the extent of damage to the gland; and the sum total grade of the two gland types on either side was assigned a US score of 0-8 for each patient. The relative importance of US score and demographic and clinical variables was assessed using stepwise multiple regression analysis after various durations of xerostomia treatment. Multiple regression analysis indicated that the baseline US score before treatment was the most important factor [standardized regression coefficient (β) = -0.523, t-statistic (t) = -7.967, P < 0.001] in predicting negative outcomes in SS patients. Treatment duration (β = 0.277, t = 4.225, P < 0.001) was also a significant but less important positive variable. On the other hand, US grading did not effectively predict treatment outcomes in non-SS patients, with treatmen...Continue Reading

References

Apr 1, 1996·AJR. American Journal of Roentgenology·Y ArijiT Nakamura
May 15, 2002·Annals of the Rheumatic Diseases·C VitaliUNKNOWN European Study Group on Classification Criteria for Sjögren's Syndrome
May 14, 2004·Annals of the Rheumatic Diseases·Y TakagiT Nakamura
Nov 10, 2007·Clinical Reviews in Allergy & Immunology·Clio P Mavragani, Haralampos M Moutsopoulos
Mar 4, 2008·Biological & Pharmaceutical Bulletin·Yuichiro YanagiHarumi Suzaki
Jul 24, 2008·Nature Clinical Practice. Rheumatology·Athanasios G Tzioufas, Haralampos M Moutsopoulos
Nov 13, 2008·The Journal of Rheumatology·Yukinori TakagiTakashi Nakamura
May 26, 2010·Annals of the Rheumatic Diseases·Yukinori TakagiTakashi Nakamura
Jul 29, 2010·JAMA : the Journal of the American Medical Association·Manuel Ramos-CasalsXavier Bosch
May 9, 2012·Arthritis Care & Research·S C ShiboskiUNKNOWN Sjögren's International Collaborative Clinical Alliance (SICCA) Research Groups
Dec 25, 2012·Annals of the Rheumatic Diseases·Claudio VitaliAthanasios G Tzioufas
Mar 23, 2013·Annals of the Rheumatic Diseases·Alexandra N ColebatchPhilip G Conaghan

❮ Previous
Next ❯

Citations

Mar 3, 2017·Joint, Bone, Spine : Revue Du Rhumatisme·Pierre GazeauValérie Devauchelle-Pensec
Feb 8, 2018·Modern Rheumatology·Takayuki SumidaHiroto Tsuboi
Dec 15, 2017·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·María Victoria MartireMarwin Gutierrez
Sep 5, 2018·European Journal of Oral Sciences·Roland JonssonKathrine Skarstein
Dec 8, 2020·Therapeutic Advances in Musculoskeletal Disease·Karishma RamsubeikJasvinder A Singh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.