Salivary glucose and antioxidant defense markers in type II diabetes mellitus

Turkish Journal of Medical Sciences
Sayeeda MussaviraBindhu Omana Sukumaran

Abstract

To evaluate salivary antioxidant defense markers, their correlation with salivary glucose, and glycemic status in type II diabetes mellitus (DM). The study included 53 diabetic patients and 40 healthy subjects. Salivary glucose, blood glucose, and uric acid (UA) were determined by specific enzymatic methods. Total antioxidant activity (AOA), glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), and total protein were determined spectrophotometrically. Salivary UA (3.12 vs. 1.89 mg/dL), GSH (47 vs. 11.92 jg/mL), and total protein (375.12 vs. 202.23 mg/dL) were significantly higher (P < 0.001; r = 0.455, 0.735, 0.498 respectively) and AOA (653.1 vs. 897.3 µmol/L) was significantly lower in the DM group (P <0.001, r = -0.431) compared to healthy controls. Among the antioxidant enzymes, CAT was significantly lower (1214 vs. 9468.9 kat) in the DM group (P < 0.001, r = -0.886). Spearman correlation analyses within the diabetic group showed a strong positive association between salivary glucose and blood glucose (P <0.001, r = 0.9), salivary glucose and GSH, and salivary glucose and UA. Salivary glucose showed a negative correlation with AOA and CAT (P = 0.008, r = -0.447) in the diabetic group. Findings of this study, showin...Continue Reading

Citations

Jan 18, 2016·Archives of Oral Biology·Jitjiroj IttichaicharoenSiriporn C Chattipakorn
Mar 12, 2016·Pathology Research International·Ilaria Peluso, Anna Raguzzini
Dec 19, 2015·Contemporary Clinical Dentistry·P V S Deepa LakshmiB Sujatha
Feb 3, 2018·Journal of Oral and Maxillofacial Pathology : JOMFP·Shreya GuptaNeelakshi Singh Rallan
Oct 18, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Shima FathiFatemeh Ahmadi-Motamayel
Feb 9, 2021·Clinical Chemistry and Laboratory Medicine : CCLM·Andrea VernerováFrantišek Švec
Jun 19, 2021·The Journal of Prosthetic Dentistry·Hitoshi Uchida, Catherine E Ovitt

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