Salivary IgG subclasses in individuals with and without homozygous IGHG gene deletions

Immunology
P E EngströmM P Lefranc

Abstract

In this study, the levels of salivary IgG1, IgG2, IgG3 and IgG4 from individuals with and without homozygous immunoglobulin heavy chain constant gene deletions were quantified by enzyme-linked immunosorbent assay (ELISA). To analyse the restriction of salivary IgG subclasses, we used unstimulated whole saliva and sera collected at the same time from individuals with homozygous gene deletions, two with G1 deletion, one with G4 deletion, six with both G2 and G4 deletions and from eight individuals without IGHG gene deletions and expressing all four IgG subclasses. The median values of salivary IgG from individuals with homozygous G1, or G4, or both G2 and G4 deletions, and from individuals expressing all four subclasses were 24.2 mg/l and 23.4 mg/l, respectively. The median values of serum IgG were 13.7 g/l and 15.9 g/l, respectively. Our results show that the salivary and serum IgG levels were both within the normal range in individuals with homozygous gene deletions of either G1, or G4, or both G2 and G4.

References

Feb 1, 1992·Acta Paediatrica·K KimD C Heiner
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Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·N MigoneA O Carbonara
Aug 1, 1994·International Archives of Allergy and Immunology·T ReunalaT Palosuo

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Citations

Nov 5, 1998·Journal of Periodontology·M Barr-AgholmeG N Engström
Apr 29, 1999·Oral Microbiology and Immunology·P E EngströmG Norhagen
Mar 14, 2014·Bioanalysis·Michael MacdonaldChamindie Punyadeera
Oct 26, 2021·Frontiers in Immunology·Constanze HeinzelAndrea Kreidenweiss

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