PMID: 9554287Apr 29, 1998Paper

Salivary immune responses after gingival immunization with tetravaccinal and bivaccinal formulations of inactivated micro-organisms

Developments in Biological Standardization
P Casetta, F Negretti

Abstract

Two groups of rats were treated separately, fourteen times during three months, by rubbing at gingival mucosa with two antigenic mixtures: (i) Staph. aureus, Str. faecalis, E. coli and Prot. vulgaris; (ii) Str. mutans and Act. viscosus. At the end of the treatments the increases of specific salivary IgAGM ranged from 202.6% (Str. faecalis) to 312.7% (E. coli) in the case of tetravaccinal association and from 123% (Act. viscosus) to 171.4% (Str. mutans) in the one of bivaccinal formulation.

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