Salivary interleukin-6 and tumor necrosis factor-alpha in patients with recurrent aphthous ulceration

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
V Vucićević BorasI Alajbeg Zilić

Abstract

Recurrent apthous ulceration (RAU) is a well known oral disease which seems to be mediated principally by the immune system. However, it is still a matter of debate which part of the immune system is implicated in its pathogenesis as a reaction to the still unknown antigen. The aim of this study was to evaluate salivary cytokines, interleukin (IL)-6, and tumor necrosis factor (TNF)-alpha. In 26 patients with minor RAU, age range of 23-49 years (mean 27.3 years), during both the acute phase and remission and in 26 healthy controls, age range of 22-64 years (mean 30.1 years), salivary IL-6 and TNF-alpha levels were determined by use of enzyme-linked immunosorbent assay (ELISA). Statistical analysis was performed by use of descriptive statistics. Significant differences in salivary TNF-alpha between healthy controls and patients with acute RAU and during the remission period were found (P < 0.001) as well as between patients with acute RAU and those during the remission period (P < 0.001). No differences in salivary IL-6 between all three groups could be found. We might conclude that elevated salivary TNF-alpha levels during acute RAU and especially during the remission period are of importance in RAU, whereas salivary IL-6 levels...Continue Reading

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Citations

Jun 26, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Camila B GalloNorberto N Sugaya
May 11, 2013·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Renata Gonçalves ResendeJeane de Fátima Correia-Silva
Nov 14, 2012·International Journal of Epidemiology·Rashida PramanikGordon B Proctor
Sep 13, 2007·The Pediatric Infectious Disease Journal·Felice FemianoNicola Cirillo
Oct 7, 2008·Journal of Periodontology·Brandon D FrodgeCraig S Miller
Dec 15, 2015·Periodontology 2000·Yazan Hassona, Crispian Scully
Mar 25, 2014·Dental Clinics of North America·Sunday O Akintoye, Martin S Greenberg
Aug 17, 2006·Oral Diseases·V Vucićević BorasZ Blazic-Potocki
Mar 10, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Ricardo Carneiro BorraPriscila Maria Andrade
Feb 15, 2013·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Mao SunYuanming Wu
Apr 25, 2014·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·E AvciS Coskun-Cevher
Oct 16, 2013·Expert Review of Anti-infective Therapy·Kim A BrogdenShireen Vali
May 8, 2018·Journal of Dental Research, Dental Clinics, Dental Prospects·Kanad ChaudhuriLingappa Ashok
Dec 14, 2018·Disease Markers·Alejandro I Lorenzo-PousoAbel García-García
Jan 13, 2021·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Chenlu ShenHua Yao
Mar 8, 2019·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Milena KosticJana Pesic Stankovic

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