Salivary pathogen and serum antibody to assess the progression of chronic periodontitis: a 24-mo prospective multicenter cohort study

Journal of Periodontal Research
T MorozumiHiromasa Yoshie

Abstract

A diagnosis of periodontitis progression is presently limited to clinical parameters such as attachment loss and radiographic imaging. The aim of this multicenter study was to monitor disease progression in patients with chronic periodontitis during a 24-mo follow-up program and to evaluate the amount of bacteria in saliva and corresponding IgG titers in serum for determining the diagnostic usefulness of each in indicating disease progression and stability. A total of 163 patients with chronic periodontitis who received trimonthly follow-up care were observed for 24 mo. The clinical parameters and salivary content of Porphyromonas gingivalis, Prevotella intermedia and Aggregatibacter actinomycetemcomitans were assessed using the modified Invader PLUS assay, and the corresponding serum IgG titers were measured using ELISA. The changes through 24 mo were analyzed using cut-off values calculated for each factor. One-way ANOVA or Fisher's exact test was used to perform between-group comparison for the data collected. Diagnostic values were calculated using Fisher's exact test. Of the 124 individuals who completed the 24-mo monitoring phase, 62 exhibited periodontitis progression, whereas 62 demonstrated stable disease. Seven patien...Continue Reading

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Citations

May 2, 2017·Photodiagnosis and Photodynamic Therapy·Yoshiaki NomuraNobuhiro Hanada
Jan 28, 2017·The Journal of Prosthetic Dentistry·Xiaodong ZhouYiming Li
Dec 6, 2017·PloS One·Yoshiaki NomuraHiromasa Yoshie
Mar 5, 2020·Journal of Oral Microbiology·Daniel Belstrøm
Sep 19, 2018·International Journal of Dentistry·Yoshiaki NomuraNobuhiro Hanada
Dec 12, 2020·Frontiers in Cellular and Infection Microbiology·Eun-Hye KimSemin Lee
Mar 7, 2021·Journal of Clinical Medicine·Yoshiaki NomuraTaneaki Nakagawa

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