Salivary phosphorus and phosphate content of beverages: implications for the treatment of uremic hyperphosphatemia

Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation
Vincenzo SavicaGuido Bellinghieri

Abstract

Hyperphosphatemia provides relevant and dangerous evidence of end-stage renal disease (ESRD) in patients undergoing periodic hemodialysis. The relationship between hyperphosphatemia and cardiovascular calcification, with the consequences of high morbidity and mortality after cardiovascular events, is well-defined. Hyperphosphatemia is treated by dietary limitation of phosphorus ingestion and by phosphate binders, but only half of ESRD patients fall within the range of K/DOQI guidelines. We summarize the results of our studies on salivary phosphate secretion in hemodialysis (HD) and chronic kidney disease (CKD) patients, and on the habit of HD patients to drink beverages with a high or low phosphate content. We also examine the correlation between hyperphosphoremia and the phosphate content of common beverages consumed by HD patients. Higher levels of salivary phosphate secretion were found in HD and in CKD patients, along with a relationship between serum phosphorus levels and a high phosphate content of beverages in HD patients.

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Citations

Dec 4, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Peter CelecPeter Boor
Sep 21, 2010·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Alastair M MathewsonAlex J Toft
Dec 8, 2009·Otolaryngologic Clinics of North America·Oded Nahlieli
May 13, 2011·Nephron. Clinical Practice·Mark S MacGregor, Maarten W Taal
Mar 20, 2020·Expert Opinion on Therapeutic Targets·Mario CozzolinoCarsten Alexander Wagner

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