Salivary Protein Profiles among HER2/neu-Receptor-Positive and -Negative Breast Cancer Patients: Support for Using Salivary Protein Profiles for Modeling Breast Cancer Progression.

Journal of Oncology
Charles F StreckfusLenora Bigler

Abstract

Purpose. The objective of this study was to compare the salivary protein profiles from individuals diagnosed with breast cancer that were either HER2/neu receptor positive or negative. Methods. Two pooled saliva specimens underwent proteomic analysis. One pooled specimen was from women diagnosed with stage IIa HER2/neu-receptor-positive breast cancer patients (n = 10) and the other was from women diagnosed with stage IIa HER2/neu-receptor-negative cancer patients (n = 10). The pooled samples were trypsinized and the peptides labeled with iTRAQ reagent. Specimens were analyzed using an LC-MS/MS mass spectrometer. Results. The results yielded approximately 71 differentially expressed proteins in the saliva specimens. There were 34 upregulated proteins and 37 downregulated proteins.

References

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Citations

Feb 21, 2013·Omics : a Journal of Integrative Biology·Valentina BravatàLuigi Minafra
Oct 30, 2012·Clinical Biochemistry·Francisco M L AmadoRui Vitorino
Jun 25, 2013·Journal of Clinical Periodontology·Manuela Gesell SalazarThomas Kocher
Sep 15, 2016·International Journal of Molecular Sciences·Óscar Rapado-GonzálezMaría Mercedes Suarez-Cunqueiro
Sep 8, 2016·Oncology Letters·Lucas DelmonicoGilda Alves

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Methods Mentioned

BETA
biopsies
biopsy
protein assay
reverse-phase chromatography
xenografts

Software Mentioned

ProQuant
Image Quant
DeCyder
PubMed Central
PathwayStudio

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