Salivary S100A8/A9 in Sjögren's syndrome accompanied by lymphoma

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Ahoud JazzarGordon B Proctor

Abstract

Sjögren's syndrome (SS) is an autoimmune inflammatory disease that affects the exocrine glands. The absence of early diagnostic markers contributes to delays in its diagnosis. Identification of changes in the protein profile of saliva is considered one of the promising strategies for the discovery of new biomarkers for SS. To identify salivary protein biomarkers with potential for use in discriminating between different lymphoma risk subgroups of SS. Parotid and whole mouth saliva samples were collected from patients with SS, including those in subgroups at higher risk of developing or with confirmed lymphoma, non-SS sicca disease controls and healthy subjects. An initial proteomics analysis by mass spectrometry (LCMSMS) identified S100A8/A9 as a biomarker and was followed by validation with an enzyme-linked immunosorbent assay (ELISA). Significant differences were found in levels of S100A8/A9 in parotid saliva but not whole mouth saliva between patients with SS compared with healthy and disease control subjects (P = 0.001 and 0.031, respectively). Subgroups of patients with SS based on lymphoma risk showed significant differences in salivary levels of S100A8/A9. The results suggest that salivary levels of S100A8/A9 can aid in ...Continue Reading

References

Feb 1, 1995·European Journal of Oral Sciences·M CuidaR Jonsson
Feb 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·F MüllerM K Fagerhol
Jun 1, 1997·European Journal of Oral Sciences·M CuidaR Jonsson
Feb 4, 1998·British Journal of Rheumatology·D G KassimosG S Panayi
May 15, 2002·Annals of the Rheumatic Diseases·C VitaliUNKNOWN European Study Group on Classification Criteria for Sjögren's Syndrome
Dec 14, 2004·Arthritis and Rheumatism·Dirk Foell, Johannes Roth
Mar 3, 2007·Annals of the New York Academy of Sciences·Philip C Fox
Jun 15, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·I SalamaJ L Jones
Jul 10, 2010·Arthritis Care & Research·Shen HuDavid T Wong
May 17, 2011·Omics : a Journal of Integrative Biology·Sandra K Al-TarawnehSompop Bencharit
May 9, 2012·Arthritis Care & Research·S C ShiboskiUNKNOWN Sjögren's International Collaborative Clinical Alliance (SICCA) Research Groups
Sep 11, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·S M OsailanS J Challacombe
Nov 14, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Aihua ZhangXijun Wang
Oct 16, 2014·British Journal of Haematology·Gaetane Nocturne, Xavier Mariette
Jan 24, 2015·Nature Reviews. Cancer·Anne R BresnickDanna B Zimmer
Jul 20, 2016·Rheumatic Diseases Clinics of North America·Stergios Katsiougiannis, David T W Wong

❮ Previous
Next ❯

Citations

Feb 19, 2019·Journal of Leukocyte Biology·Jason G KayMichelle B Visser
Jan 24, 2019·Journal of Immunology Research·Jeremy Kiripolsky, Jill M Kramer
Nov 7, 2019·International Journal of Molecular Sciences·Chiara RizzoGiuliana Guggino
Jan 1, 2020·Journal of Biological Research·Katerina R Katsani, Dimitra Sakellari
Aug 8, 2021·International Journal of Molecular Sciences·Katie DunphyDespina Bazou

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.