PMID: 43073Oct 1, 1979

Salivary secretion evoked by H80/62, (+/-)-1-(4-hydroxyphenoxy)-3-isopropylamino-2-propranol, a new beta 1-selective adrenoceptor agonist

Acta Pharmacologica Et Toxicologica
J Ekström


H80/62, recently introduced as a beta 1-selective adrenoceptor agonist, caused a long-lasting flow of saliva from parotid and submaxillary glands of the rat. The effect of H80/62 was prevented by propranolol or a beta 1-selective blocker. The drug did not exert its effect via the sympathetic postganglionic nerves; and it was not taken up by the neuronal amine pump. Sympathetically decentralized or denervated glands acquired a supersensitivity of the postjunctional type to H80/62.


Nov 10, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·E CarlssonB Tångstrand
Mar 1, 1978·British Journal of Pharmacology·B CarlsööR Henriksson
May 31, 1978·European Journal of Clinical Pharmacology·G JohnssonJ Wikstrand
Jun 1, 1974·The Journal of Physiology·U Delfs, N Emmelin

Related Concepts

Secretion of Saliva
Saliva - SpecimenType
Adrenergic beta-Agonists
Secretory Rate
Adrenergic Receptor

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