PMID: 43073Oct 1, 1979

Salivary secretion evoked by H80/62, (+/-)-1-(4-hydroxyphenoxy)-3-isopropylamino-2-propranol, a new beta 1-selective adrenoceptor agonist

Acta Pharmacologica Et Toxicologica
J Ekström

Abstract

H80/62, recently introduced as a beta 1-selective adrenoceptor agonist, caused a long-lasting flow of saliva from parotid and submaxillary glands of the rat. The effect of H80/62 was prevented by propranolol or a beta 1-selective blocker. The drug did not exert its effect via the sympathetic postganglionic nerves; and it was not taken up by the neuronal amine pump. Sympathetically decentralized or denervated glands acquired a supersensitivity of the postjunctional type to H80/62.

Citations

Nov 10, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·E CarlssonB Tångstrand
Mar 1, 1978·British Journal of Pharmacology·B CarlsööR Henriksson
May 31, 1978·European Journal of Clinical Pharmacology·G JohnssonJ Wikstrand
Jun 1, 1974·The Journal of Physiology·U Delfs, N Emmelin

Related Concepts

Nervousness
Exertion
Amines
Secretion of Saliva
Saliva - SpecimenType
Adrenergic beta-Agonists
Secretory Rate
Propanolamines
Neuronal
Adrenergic Receptor

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.